Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-κB pathway

Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-κB pathway

Abstract Objective Neuroinflammation plays a critical role in central nervous system diseases. Exosomal miRNAs released from various cells are implicated in cell-to-cell communication. Prior studies have placed substantial emphasis on the role of cytokines in mast cell-microglia interactions during...

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Bibliographic Details
Main Authors: Liuqing Hu, Linjie Si, Xiaonan Dai, Hongquan Dong, Zijian Ma, Zhaochu Sun, Nana Li, Huanhuan Sha, Yinan Chen, Yanning Qian, Zhiyuan Zhang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Neuroinflammation
Exosome
miR-409-3p
Online Access:https://doi.org/10.1186/s12974-021-02110-5

Internet

https://doi.org/10.1186/s12974-021-02110-5

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