Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus)
One important reason for non-use of medicinal drugs is their hepatotoxicity. The search for new natural biologically active substances with hepatoprotective properties and which are cost-effective is an important task today. This article presents the data on the impact of the fodder-dietary suppleme...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Oles Honchar Dnipropetrovsk National University
2016-10-01
|
Series: | Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ |
Subjects: | |
Online Access: | http://ecology.dp.ua/index.php/ECO/article/view/689 |
id |
doaj-f9c7033f0c504d9483056e1dfb2c7de6 |
---|---|
record_format |
Article |
spelling |
doaj-f9c7033f0c504d9483056e1dfb2c7de62020-11-24T22:54:16ZengOles Honchar Dnipropetrovsk National UniversityVìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ2310-08422312-301X2016-10-0124210.15421/011655679Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus)D. Serova0O. Taran1O. Dyomshina2Оles Honchar Dnipropetrovsk National UniversityОles Honchar Dnipropetrovsk National UniversityОles Honchar Dnipropetrovsk National UniversityOne important reason for non-use of medicinal drugs is their hepatotoxicity. The search for new natural biologically active substances with hepatoprotective properties and which are cost-effective is an important task today. This article presents the data on the impact of the fodder-dietary supplement Humilid alone and in combination with ascorbic acid, and Eco-Impulse on the liver of Mongolian gerbils (Meriones unguiculatus Milne-Edwards, 1867). Hepatomodulation of properties of humic substances in the Humilid confirmed that stimulation of the activity of the enzyme transaminase increases the total amount of protein, especially in combination with ascorbic acid. There was inhibition of accumulation of oxidized products in the cell due to activation of catalase and superoxidedismutase. Intensification of catalase is regarded as one of the important mechanisms of adaptation of the cell under the influence of xenobiotics. Addition of ascorbic acid to the solution Humilid increased the antioxidant action of its active ingredients both through its own antioxidant properties and protection of humic acids from oxidation. Formation of response in liver cells of gerbils receiving active ingredients of the drug Eco-Impulse was accompanied by an increase in the number of TBA-active products and cytochrome C, which indicates the development of oxidative stress, which is accompanied by increased permeability of mitochondrial membranes. The results indicate the hepatoprotective properties of the active ingredients of the drug Humilid, alone and in combination with ascorbic acid, and the need for correcting the concentration of the drug Eco-Impulse for use in clinical practice.http://ecology.dp.ua/index.php/ECO/article/view/689HumilidEco-ІmpulseaminotransferasescatalasesuperoxidedismutaseTBA-active productscytochrome C |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
D. Serova O. Taran O. Dyomshina |
spellingShingle |
D. Serova O. Taran O. Dyomshina Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus) Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ Humilid Eco-Іmpulse aminotransferases catalase superoxidedismutase TBA-active products cytochrome C |
author_facet |
D. Serova O. Taran O. Dyomshina |
author_sort |
D. Serova |
title |
Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus) |
title_short |
Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus) |
title_full |
Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus) |
title_fullStr |
Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus) |
title_full_unstemmed |
Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus) |
title_sort |
biological activity of humic substances in the liver of mongolian gerbils (meriones unguiculatus) |
publisher |
Oles Honchar Dnipropetrovsk National University |
series |
Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ |
issn |
2310-0842 2312-301X |
publishDate |
2016-10-01 |
description |
One important reason for non-use of medicinal drugs is their hepatotoxicity. The search for new natural biologically active substances with hepatoprotective properties and which are cost-effective is an important task today. This article presents the data on the impact of the fodder-dietary supplement Humilid alone and in combination with ascorbic acid, and Eco-Impulse on the liver of Mongolian gerbils (Meriones unguiculatus Milne-Edwards, 1867). Hepatomodulation of properties of humic substances in the Humilid confirmed that stimulation of the activity of the enzyme transaminase increases the total amount of protein, especially in combination with ascorbic acid. There was inhibition of accumulation of oxidized products in the cell due to activation of catalase and superoxidedismutase. Intensification of catalase is regarded as one of the important mechanisms of adaptation of the cell under the influence of xenobiotics. Addition of ascorbic acid to the solution Humilid increased the antioxidant action of its active ingredients both through its own antioxidant properties and protection of humic acids from oxidation. Formation of response in liver cells of gerbils receiving active ingredients of the drug Eco-Impulse was accompanied by an increase in the number of TBA-active products and cytochrome C, which indicates the development of oxidative stress, which is accompanied by increased permeability of mitochondrial membranes. The results indicate the hepatoprotective properties of the active ingredients of the drug Humilid, alone and in combination with ascorbic acid, and the need for correcting the concentration of the drug Eco-Impulse for use in clinical practice. |
topic |
Humilid Eco-Іmpulse aminotransferases catalase superoxidedismutase TBA-active products cytochrome C |
url |
http://ecology.dp.ua/index.php/ECO/article/view/689 |
work_keys_str_mv |
AT dserova biologicalactivityofhumicsubstancesintheliverofmongoliangerbilsmerionesunguiculatus AT otaran biologicalactivityofhumicsubstancesintheliverofmongoliangerbilsmerionesunguiculatus AT odyomshina biologicalactivityofhumicsubstancesintheliverofmongoliangerbilsmerionesunguiculatus |
_version_ |
1725661021439262720 |