Spike Glycoprotein-Mediated Entry of SARS Coronaviruses
Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses and causes of epidemic diseases that have resulted in public health emergencies worldwide. Angiotensin-converting enzyme 2 (ACE2) is the receptor that allows the entry o...
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doaj-f9da053271c346bfbe2e3ddcb274a6132020-11-25T03:57:01ZengMDPI AGViruses1999-49152020-11-01121289128910.3390/v12111289Spike Glycoprotein-Mediated Entry of SARS CoronavirusesLin Wang0Ye Xiang1Center for Infectious Disease Research, Beijing Frontier Research Center for Biological Structure & Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, ChinaCenter for Infectious Disease Research, Beijing Frontier Research Center for Biological Structure & Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, ChinaSevere acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses and causes of epidemic diseases that have resulted in public health emergencies worldwide. Angiotensin-converting enzyme 2 (ACE2) is the receptor that allows the entry of these two viruses into host cells, a key step in the life cycle of the pathogens. The characterization of the interactions of ACE2 with the viral spike glycoproteins and structural studies of the ACE2-binding-induced conformational changes in the viral spike glycoproteins have furthered our understanding of the entry processes of these two viruses, and these studies provide useful information that will facilitate the development of antiviral agents and vaccines to control the diseases.https://www.mdpi.com/1999-4915/12/11/1289SARS coronavirusesCOVID-19spike glycoproteinentryreceptor bindingconformational change |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Wang Ye Xiang |
spellingShingle |
Lin Wang Ye Xiang Spike Glycoprotein-Mediated Entry of SARS Coronaviruses Viruses SARS coronaviruses COVID-19 spike glycoprotein entry receptor binding conformational change |
author_facet |
Lin Wang Ye Xiang |
author_sort |
Lin Wang |
title |
Spike Glycoprotein-Mediated Entry of SARS Coronaviruses |
title_short |
Spike Glycoprotein-Mediated Entry of SARS Coronaviruses |
title_full |
Spike Glycoprotein-Mediated Entry of SARS Coronaviruses |
title_fullStr |
Spike Glycoprotein-Mediated Entry of SARS Coronaviruses |
title_full_unstemmed |
Spike Glycoprotein-Mediated Entry of SARS Coronaviruses |
title_sort |
spike glycoprotein-mediated entry of sars coronaviruses |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2020-11-01 |
description |
Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses and causes of epidemic diseases that have resulted in public health emergencies worldwide. Angiotensin-converting enzyme 2 (ACE2) is the receptor that allows the entry of these two viruses into host cells, a key step in the life cycle of the pathogens. The characterization of the interactions of ACE2 with the viral spike glycoproteins and structural studies of the ACE2-binding-induced conformational changes in the viral spike glycoproteins have furthered our understanding of the entry processes of these two viruses, and these studies provide useful information that will facilitate the development of antiviral agents and vaccines to control the diseases. |
topic |
SARS coronaviruses COVID-19 spike glycoprotein entry receptor binding conformational change |
url |
https://www.mdpi.com/1999-4915/12/11/1289 |
work_keys_str_mv |
AT linwang spikeglycoproteinmediatedentryofsarscoronaviruses AT yexiang spikeglycoproteinmediatedentryofsarscoronaviruses |
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