The relationship between some endometrial secretion cytokines and in vitro fertilization
Background: Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity. Objective: The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleuk...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Shahid Sadoughi University of Medical Science, Yazd, Iran
2015-09-01
|
Series: | Iranian Journal of Reproductive Medicine |
Subjects: | |
Online Access: | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1648/885 |
id |
doaj-f9e28936b8dd4673bd7b52861598c642 |
---|---|
record_format |
Article |
spelling |
doaj-f9e28936b8dd4673bd7b52861598c6422020-11-25T00:38:58ZengShahid Sadoughi University of Medical Science, Yazd, IranIranian Journal of Reproductive Medicine1680-64332008-21772015-09-01139557562The relationship between some endometrial secretion cytokines and in vitro fertilization Mohammad Ehsan Rahiminejad0Amirhossein Moaddab1Mehrnoosh Ebrahimi2Soghra Rabiee3Alireza Zamani4Mohammad Ezzati5Alireza Abdollah Shamshirsaz6Department of Obstetrics & Gynecology, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran.Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.Department of Obstetrics & Gynecology, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran.Department of Obstetrics & Gynecology, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran.Department of Immunology and Hematology, Hamadan University of Medical Sciences and Health Services, Hamadan, IranDepartment of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX, USADepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.Background: Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity. Objective: The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), interferon gamma-induced protein 10 (IP-10), and monocyte chemoattractant protein (MCP). Materials and Methods: In a prospective cohort study, 50 women selected for IVF met the study inclusion criteria. All the patients underwent endometrial secretion aspiration prior to embryo transfer. The level of IL-1β, TNF-α, IP-10 and MCP were analyzed by enzyme-linked immunosorbent assay method using special standard kits. To detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation. Results: Five samples were excluded. Nine women (20%) had successful clinical pregnancies, which resulted in live birth. Other 36 women (80%) were classified as failed pregnancy. Comparison of cytokine levels showed lower concentrations of TNF-α, IP-10, and MCP in the group with successful clinical pregnancy compared to the group with failed pregnancy (p=0.007, 0.005 and 0.001, respectively). However, no significant difference was revealed in IL-1β levels between two groups (p=0.614). Conclusion: The current study suggested that lower concentrations of TNF-α, IP-10, and MCP in endometrial secretions might be associated with improved endometrial receptivity and IVF outcome. Regarding IL-1β, no statistically significant differences were seen between the groups with and without successful pregnancy. http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1648/885CytokineIn vitro fertilizationOutcomeEndometriumImplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Ehsan Rahiminejad Amirhossein Moaddab Mehrnoosh Ebrahimi Soghra Rabiee Alireza Zamani Mohammad Ezzati Alireza Abdollah Shamshirsaz |
spellingShingle |
Mohammad Ehsan Rahiminejad Amirhossein Moaddab Mehrnoosh Ebrahimi Soghra Rabiee Alireza Zamani Mohammad Ezzati Alireza Abdollah Shamshirsaz The relationship between some endometrial secretion cytokines and in vitro fertilization Iranian Journal of Reproductive Medicine Cytokine In vitro fertilization Outcome Endometrium Implantation |
author_facet |
Mohammad Ehsan Rahiminejad Amirhossein Moaddab Mehrnoosh Ebrahimi Soghra Rabiee Alireza Zamani Mohammad Ezzati Alireza Abdollah Shamshirsaz |
author_sort |
Mohammad Ehsan Rahiminejad |
title |
The relationship between some endometrial secretion cytokines and in vitro fertilization |
title_short |
The relationship between some endometrial secretion cytokines and in vitro fertilization |
title_full |
The relationship between some endometrial secretion cytokines and in vitro fertilization |
title_fullStr |
The relationship between some endometrial secretion cytokines and in vitro fertilization |
title_full_unstemmed |
The relationship between some endometrial secretion cytokines and in vitro fertilization |
title_sort |
relationship between some endometrial secretion cytokines and in vitro fertilization |
publisher |
Shahid Sadoughi University of Medical Science, Yazd, Iran |
series |
Iranian Journal of Reproductive Medicine |
issn |
1680-6433 2008-2177 |
publishDate |
2015-09-01 |
description |
Background: Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity.
Objective: The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), interferon gamma-induced protein 10 (IP-10), and monocyte chemoattractant protein (MCP).
Materials and Methods: In a prospective cohort study, 50 women selected for IVF met the study inclusion criteria. All the patients underwent endometrial secretion aspiration prior to embryo transfer. The level of IL-1β, TNF-α, IP-10 and MCP were analyzed by enzyme-linked immunosorbent assay method using special standard kits. To detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation.
Results: Five samples were excluded. Nine women (20%) had successful clinical pregnancies, which resulted in live birth. Other 36 women (80%) were classified as failed pregnancy. Comparison of cytokine levels showed lower concentrations of TNF-α, IP-10, and MCP in the group with successful clinical pregnancy compared to the group with failed pregnancy (p=0.007, 0.005 and 0.001, respectively). However, no significant difference was revealed in IL-1β levels between two groups (p=0.614).
Conclusion: The current study suggested that lower concentrations of TNF-α, IP-10, and MCP in endometrial secretions might be associated with improved endometrial receptivity and IVF outcome. Regarding IL-1β, no statistically significant differences were seen between the groups with and without successful pregnancy.
|
topic |
Cytokine In vitro fertilization Outcome Endometrium Implantation |
url |
http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1648/885 |
work_keys_str_mv |
AT mohammadehsanrahiminejad therelationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT amirhosseinmoaddab therelationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT mehrnooshebrahimi therelationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT soghrarabiee therelationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT alirezazamani therelationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT mohammadezzati therelationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT alirezaabdollahshamshirsaz therelationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT mohammadehsanrahiminejad relationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT amirhosseinmoaddab relationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT mehrnooshebrahimi relationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT soghrarabiee relationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT alirezazamani relationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT mohammadezzati relationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization AT alirezaabdollahshamshirsaz relationshipbetweensomeendometrialsecretioncytokinesandinvitrofertilization |
_version_ |
1725295550070259712 |