Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis

Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis

Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat...

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Bibliographic Details
Main Authors: Xue Yao, Yan Zhang, Jian Hao, Hui-Quan Duan, Chen-Xi Zhao, Chao Sun, Bo Li, Bao-You Fan, Xu Wang, Wen-Xiang Li, Xuan-Hao Fu, Yong Hu, Chang Liu, Xiao-Hong Kong, Shi-Qing Feng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; iron; spinal cord injury; secondary injury; ferroptosis; deferoxamine; GPX4; xCT; treatment; astrogliosis; lipid peroxidation; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=532;epage=541;aulast=Yao

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