Chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathy
BackgroundChronic inflammatory demyelinating polyneuropathy (CIDP) is a common yet underdiagnosed cause of potentially treatable chronic sensorimotor neuropathy. The classical form of the disease is characterised by symmetrical weakness in both distal and proximal muscle groups accompanied by sensor...
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2020-07-01
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doaj-f9f2c9ed6c944433bd8317b67bbe76192021-03-30T14:00:12ZengBMJ Publishing GroupBMJ Neurology Open2632-61402020-07-012110.1136/bmjno-2020-000045Chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathyCecilia Cappelen-Smith0Judith Spies1Department of Neurophysiology, Liverpool Hospital, Liverpool, New South Wales, AustraliaDepartment of Neurology, Royal Prince Alfred Hospital, Camperdown, New South Wales, AustraliaBackgroundChronic inflammatory demyelinating polyneuropathy (CIDP) is a common yet underdiagnosed cause of potentially treatable chronic sensorimotor neuropathy. The classical form of the disease is characterised by symmetrical weakness in both distal and proximal muscle groups accompanied by sensory dysfunction and diminished tendon reflexes lasting more than 2 months.MethodThe diagnosis of CIDP is supplemented by electrodiagnostic studies and biopsy findings confirming demyelination, in accordance with well-established diagnostic criteria. Atypical presentations of CIDP often pose a diagnostic challenge.ResultsIn this paper, we present a case of isolated lower limb involvement due to CIDP to raise awareness of this focal lower limb variant. Of particular, significance is the use of lumbosacral plexus MRI to assist in the diagnosis.ConclusionFocal CIDP is an atypical presentation that should be considered in patients presenting with chronic monomelic neuropathy and should be investigated with electrodiagnostic studies, lumbar puncture, nerve biopsy and MRI of the nerve roots and plexuses.https://neurologyopen.bmj.com/content/2/1/e000045.full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cecilia Cappelen-Smith Judith Spies |
spellingShingle |
Cecilia Cappelen-Smith Judith Spies Chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathy BMJ Neurology Open |
author_facet |
Cecilia Cappelen-Smith Judith Spies |
author_sort |
Cecilia Cappelen-Smith |
title |
Chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathy |
title_short |
Chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathy |
title_full |
Chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathy |
title_fullStr |
Chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathy |
title_full_unstemmed |
Chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathy |
title_sort |
chronic inflammatory demyelinating polyradiculoneuropathy presenting as predominantly sciatic monomelic neuropathy |
publisher |
BMJ Publishing Group |
series |
BMJ Neurology Open |
issn |
2632-6140 |
publishDate |
2020-07-01 |
description |
BackgroundChronic inflammatory demyelinating polyneuropathy (CIDP) is a common yet underdiagnosed cause of potentially treatable chronic sensorimotor neuropathy. The classical form of the disease is characterised by symmetrical weakness in both distal and proximal muscle groups accompanied by sensory dysfunction and diminished tendon reflexes lasting more than 2 months.MethodThe diagnosis of CIDP is supplemented by electrodiagnostic studies and biopsy findings confirming demyelination, in accordance with well-established diagnostic criteria. Atypical presentations of CIDP often pose a diagnostic challenge.ResultsIn this paper, we present a case of isolated lower limb involvement due to CIDP to raise awareness of this focal lower limb variant. Of particular, significance is the use of lumbosacral plexus MRI to assist in the diagnosis.ConclusionFocal CIDP is an atypical presentation that should be considered in patients presenting with chronic monomelic neuropathy and should be investigated with electrodiagnostic studies, lumbar puncture, nerve biopsy and MRI of the nerve roots and plexuses. |
url |
https://neurologyopen.bmj.com/content/2/1/e000045.full |
work_keys_str_mv |
AT ceciliacappelensmith chronicinflammatorydemyelinatingpolyradiculoneuropathypresentingaspredominantlysciaticmonomelicneuropathy AT judithspies chronicinflammatorydemyelinatingpolyradiculoneuropathypresentingaspredominantlysciaticmonomelicneuropathy |
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