Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients
Abstract Background Preference assessments of patients with rheumatoid arthritis can support clinical therapeutic decisions for including biologic and targeted synthetic medicines to use. This study assesses patient preferences for attributes of second-line therapies and heterogeneity within these p...
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doaj-f9fa4782feb64f9d92cdbe8252db38f92020-12-20T12:40:35ZengBMCArthritis Research & Therapy1478-63622020-12-0122111010.1186/s13075-020-02391-wPatient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patientsKarin Schölin Bywall0Ulrik Kihlbom1Mats Hansson2Marie Falahee3Karim Raza4Eva Baecklund5Jorien Veldwijk6Centre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala UniversityCentre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala UniversityCentre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala UniversityInstitute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth HospitalInstitute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth HospitalDepartment of Medical Sciences, Rheumatology, Uppsala UniversityErasmus School of Health Policy & Management, and Erasmus Choice Modelling Centre, Erasmus University RotterdamAbstract Background Preference assessments of patients with rheumatoid arthritis can support clinical therapeutic decisions for including biologic and targeted synthetic medicines to use. This study assesses patient preferences for attributes of second-line therapies and heterogeneity within these preferences to estimate the relative importance of treatment characteristics and to calculate the minimum benefit levels patients require to accept higher levels of side effects. Methods Between November 2018 to August 2019, patients with rheumatoid arthritis were recruited to a survey containing demographic and disease-related questions as well as a discrete choice experiment to measure their preferences for second-line therapies using biologics or Janus kinases inhibitors. Treatment characteristics included were route of administration, frequency of use, probability of mild short-term side effects, probability of side effects changing appearance, probability of psychological side effects, probability of severe side effects and effectiveness of treatment. Results A total of 358 patients were included in the analysis. A latent class analysis revealed three preference patterns: (1) treatment effectiveness as the single most important attribute, (2) route of administration as the most important attribute, closely followed by frequency of use and psychological side effects and (3) severe side effects as the most important attribute followed by psychological side effects. In addition, disease duration and mild side effects influenced the patients’ choices. Conclusion Respondents found either effectiveness, route of administration or severe side effects as the most important attribute. Patients noting effectiveness as most important were more willing than other patients to accept higher risks of side effects.https://doi.org/10.1186/s13075-020-02391-wDiscrete choice experimentPatient preferencesRheumatoid arthritisSecond-line treatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karin Schölin Bywall Ulrik Kihlbom Mats Hansson Marie Falahee Karim Raza Eva Baecklund Jorien Veldwijk |
spellingShingle |
Karin Schölin Bywall Ulrik Kihlbom Mats Hansson Marie Falahee Karim Raza Eva Baecklund Jorien Veldwijk Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients Arthritis Research & Therapy Discrete choice experiment Patient preferences Rheumatoid arthritis Second-line treatment |
author_facet |
Karin Schölin Bywall Ulrik Kihlbom Mats Hansson Marie Falahee Karim Raza Eva Baecklund Jorien Veldwijk |
author_sort |
Karin Schölin Bywall |
title |
Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients |
title_short |
Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients |
title_full |
Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients |
title_fullStr |
Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients |
title_full_unstemmed |
Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients |
title_sort |
patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of swedish patients |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2020-12-01 |
description |
Abstract Background Preference assessments of patients with rheumatoid arthritis can support clinical therapeutic decisions for including biologic and targeted synthetic medicines to use. This study assesses patient preferences for attributes of second-line therapies and heterogeneity within these preferences to estimate the relative importance of treatment characteristics and to calculate the minimum benefit levels patients require to accept higher levels of side effects. Methods Between November 2018 to August 2019, patients with rheumatoid arthritis were recruited to a survey containing demographic and disease-related questions as well as a discrete choice experiment to measure their preferences for second-line therapies using biologics or Janus kinases inhibitors. Treatment characteristics included were route of administration, frequency of use, probability of mild short-term side effects, probability of side effects changing appearance, probability of psychological side effects, probability of severe side effects and effectiveness of treatment. Results A total of 358 patients were included in the analysis. A latent class analysis revealed three preference patterns: (1) treatment effectiveness as the single most important attribute, (2) route of administration as the most important attribute, closely followed by frequency of use and psychological side effects and (3) severe side effects as the most important attribute followed by psychological side effects. In addition, disease duration and mild side effects influenced the patients’ choices. Conclusion Respondents found either effectiveness, route of administration or severe side effects as the most important attribute. Patients noting effectiveness as most important were more willing than other patients to accept higher risks of side effects. |
topic |
Discrete choice experiment Patient preferences Rheumatoid arthritis Second-line treatment |
url |
https://doi.org/10.1186/s13075-020-02391-w |
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