New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.
The majority of expression quantitative trait locus (eQTL) studies have been carried out in single tissues or cell types, using methods that ignore information shared across tissues. Although global analysis of RNA expression in multiple tissues is now feasible, few integrated statistical frameworks...
Main Authors: | Enrico Petretto, Leonardo Bottolo, Sarah R Langley, Matthias Heinig, Chris McDermott-Roe, Rizwan Sarwar, Michal Pravenec, Norbert Hübner, Timothy J Aitman, Stuart A Cook, Sylvia Richardson |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-04-01
|
Series: | PLoS Computational Biology |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20386736/?tool=EBI |
Similar Items
-
Genome-wide co-expression analysis in multiple tissues.
by: Ian C Grieve, et al.
Published: (2008-01-01) -
Heritability and tissue specificity of expression quantitative trait loci.
by: Enrico Petretto, et al.
Published: (2006-10-01) -
Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
by: Philip M. Coan, et al.
Published: (2017-03-01) -
R2GUESS: A Graphics Processing Unit-Based R Package for Bayesian Variable Selection Regression of Multivariate Responses
by: Benoît Liquet, et al.
Published: (2016-01-01) -
Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules.
by: Xiaolin Xiao, et al.
Published: (2014-01-01)