Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer

• Main Authors: Toshihiko Takeiwa, Kazuhiro Ikeda, Kuniko Horie-Inoue, Satoshi Inoue
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-04-01
• Series: Frontiers in Cell and Developmental Biology
• Subjects: ovarian cancer; ovary; apoptosis; long non-coding RNA; transcriptional regulation; histone modification complex
• Online Access: https://www.frontiersin.org/articles/10.3389/fcell.2021.641963/full

Ovarian cancer is a health-threatening malignancy of ovary in female reproductive systems and one of the most common gynecological malignancies worldwide. Due to rare early symptoms, ovarian cancers are often diagnosed at advanced stages and exhibit poor prognosis. Thus, efforts have been paid to develop alternative diagnostic and therapeutic strategies for the disease. Recent studies have presented that some long non-coding RNAs (lncRNAs) play roles in apoptosis of ovarian cancer cells through various mechanisms involved in the regulation of transcription factors, histone modification complexes, miRNAs, and protein stability. Because evasion of apoptosis in cancer cells facilitates to promote tumor progression and therapy resistance, apoptosis regulatory mechanisms of lncRNAs may be promising new targets in ovarian cancer. In this review, we introduce the recent findings in regard to the molecular mechanisms of apoptosis-related lncRNAs in ovarian cancer cells.