Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators
A diversity of immune tolerance mechanisms have evolved to protect normal tissues from immune damage. Immune regulatory cells are critical contributors to peripheral tolerance. These regulatory cells, exemplified by the CD4 + Foxp3 + regulatory T (Treg) cells and a recently identified population nam...
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Online Access: | https://doi.org/10.3727/096368909X480314 |
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doaj-fa08c1ba856740849badac342d8526ab2020-11-25T03:28:47ZengSAGE PublishingCell Transplantation0963-68971555-38922010-03-011910.3727/096368909X480314Immune Tolerance Induction by Integrating Innate and Adaptive Immune RegulatorsJun Suzuki0Camillo Ricordi1Zhibin Chen M.D., Ph.D.2Department of Microbiology and Immunology, University of Miami, Miami, FL, USAKarolinska Institute, Stockholm, SwedenDiabetes Research Institute, University of Miami, Miami, FL, USAA diversity of immune tolerance mechanisms have evolved to protect normal tissues from immune damage. Immune regulatory cells are critical contributors to peripheral tolerance. These regulatory cells, exemplified by the CD4 + Foxp3 + regulatory T (Treg) cells and a recently identified population named myeloid-derived suppressor cells (MDSCs), regulate immune responses and limiting immune-mediated pathology. In a chronic inflammatory setting, such as allograft-directed immunity, there may be a dynamic “cross-talk” between the innate and adaptive immunomodulatory mechanisms for an integrated control of immune damage. CTLA4-B7-based interaction between the two branches may function as a molecular “bridge” to facilitate such “cross-talk.” Understanding the interplays among Treg cells, innate suppressors, and pathogenic effector T (Teff) cells will be critical in the future to assist in the development of therapeutic strategies to enhance and synergize physiological immunosuppressive elements in the innate and adaptive immune system. Successful development of localized strategies of regulatory cell therapies could circumvent the requirement for very high number of cells and decrease the risks associated with systemic immunosuppression. To realize the potential of innate and adaptive immune regulators for the still elusive goal of immune tolerance induction, adoptive cell therapies may also need to be coupled with agents enhancing endogenous tolerance mechanisms.https://doi.org/10.3727/096368909X480314 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Suzuki Camillo Ricordi Zhibin Chen M.D., Ph.D. |
spellingShingle |
Jun Suzuki Camillo Ricordi Zhibin Chen M.D., Ph.D. Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators Cell Transplantation |
author_facet |
Jun Suzuki Camillo Ricordi Zhibin Chen M.D., Ph.D. |
author_sort |
Jun Suzuki |
title |
Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators |
title_short |
Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators |
title_full |
Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators |
title_fullStr |
Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators |
title_full_unstemmed |
Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators |
title_sort |
immune tolerance induction by integrating innate and adaptive immune regulators |
publisher |
SAGE Publishing |
series |
Cell Transplantation |
issn |
0963-6897 1555-3892 |
publishDate |
2010-03-01 |
description |
A diversity of immune tolerance mechanisms have evolved to protect normal tissues from immune damage. Immune regulatory cells are critical contributors to peripheral tolerance. These regulatory cells, exemplified by the CD4 + Foxp3 + regulatory T (Treg) cells and a recently identified population named myeloid-derived suppressor cells (MDSCs), regulate immune responses and limiting immune-mediated pathology. In a chronic inflammatory setting, such as allograft-directed immunity, there may be a dynamic “cross-talk” between the innate and adaptive immunomodulatory mechanisms for an integrated control of immune damage. CTLA4-B7-based interaction between the two branches may function as a molecular “bridge” to facilitate such “cross-talk.” Understanding the interplays among Treg cells, innate suppressors, and pathogenic effector T (Teff) cells will be critical in the future to assist in the development of therapeutic strategies to enhance and synergize physiological immunosuppressive elements in the innate and adaptive immune system. Successful development of localized strategies of regulatory cell therapies could circumvent the requirement for very high number of cells and decrease the risks associated with systemic immunosuppression. To realize the potential of innate and adaptive immune regulators for the still elusive goal of immune tolerance induction, adoptive cell therapies may also need to be coupled with agents enhancing endogenous tolerance mechanisms. |
url |
https://doi.org/10.3727/096368909X480314 |
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