Single and Repeated Administration of Methylphenidate Modulates Synaptic Plasticity in Opposite Directions via Insertion of AMPA Receptors in Rat Hippocampal Neurons

Single and Repeated Administration of Methylphenidate Modulates Synaptic Plasticity in Opposite Directions via Insertion of AMPA Receptors in Rat Hippocampal Neurons

Methylphenidate (MPH) is widely used in the treatment of Attention Deficit Hyperactivity Disorder. Several lines of evidence support that MPH can modulate learning and memory processes in different ways including improvement and impairment of test performances. A relevant factor in the efficacy of t...

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Bibliographic Details
Main Authors: Claudia Carvallo, Darwin Contreras, Gonzalo Ugarte, Ricardo Delgado, Floria Pancetti, Carlos Rozas, Ricardo Piña, Luis Constandil, Marc L. Zeise, Bernardo Morales
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
methylphenidate
AMPA receptor
synaptic plasticity
hippocampus
LTP
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01485/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01485/full

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