Cholesterol accelerates the binding of Alzheimer’s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation.

Cholesterol accelerates the binding of Alzheimer’s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation.

Age-related alterations of membrane lipids in brain cell membranes together with high blood cholesterol are considered as major risk factors for Alzheimer’s disease. Yet the molecular mechanisms by which these factors increase Alzheimer’s risk are mostly unknown. In lipid raft domains of the plasma...

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Bibliographic Details
Main Authors: Jacques eFantini, Nouara eYahi, Nicolas eGarmy
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Physiology
Subjects:
Cholesterol
Alzheimer
ganglioside
molecular modelling
lipid raft
GM1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00120/full

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