Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University
The production of 18F, 11C, 13N, and 15O positron emitting radionuclides for PET imaging is usually accomplished in Nuclear Medicine Departments through direct nuclear reactions induced by protons accelerated by compact medical cyclotrons on liquid or gaseous targets. Messina University has funded t...
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Accademia Peloritana dei Pericolanti
2017-02-01
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http://dx.doi.org/10.1478/AAPP.951A1
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doaj-fa114277795349c59e35bb0859ef8b452020-11-24T23:53:40ZengAccademia Peloritana dei PericolantiAtti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali0365-03591825-12422017-02-01951A110.1478/AAPP.951A1AAPP.951A1Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina UniversityLucrezia AuditoreErnesto AmatoAntonio ItalianoBenedetta PaganoSergio BaldariThe production of 18F, 11C, 13N, and 15O positron emitting radionuclides for PET imaging is usually accomplished in Nuclear Medicine Departments through direct nuclear reactions induced by protons accelerated by compact medical cyclotrons on liquid or gaseous targets. Messina University has funded the construction of a PET-cyclotron-radio-chemistry plant at the Messina University Hospital, equipped with a 11 MeV self-shielded cyclotron. We estimated the expected production yields of these nuclides, accounting for target thickness, production of other radioactive nuclides, and time effects on the irradiated target purity. To this aim, both TALYS code (v. 1.8) and an analytical approach based on EXFOR experimental data were used. The general agreement between the two approaches, and with the available literature data, allows to assess the expected yields at the End of Bombardment, and relative target purities, to be used for further radiopharmaceutical preparation steps. http://dx.doi.org/10.1478/AAPP.951A1 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucrezia Auditore Ernesto Amato Antonio Italiano Benedetta Pagano Sergio Baldari |
spellingShingle |
Lucrezia Auditore Ernesto Amato Antonio Italiano Benedetta Pagano Sergio Baldari Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali |
author_facet |
Lucrezia Auditore Ernesto Amato Antonio Italiano Benedetta Pagano Sergio Baldari |
author_sort |
Lucrezia Auditore |
title |
Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University |
title_short |
Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University |
title_full |
Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University |
title_fullStr |
Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University |
title_full_unstemmed |
Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University |
title_sort |
evaluation of the production capabilities of 18f, 11c, 13n and 15o pet isotopes at the pet-cyclotron-radiochemistry site of messina university |
publisher |
Accademia Peloritana dei Pericolanti |
series |
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali |
issn |
0365-0359 1825-1242 |
publishDate |
2017-02-01 |
description |
The production of 18F, 11C, 13N, and 15O positron emitting radionuclides for PET imaging is usually accomplished in Nuclear Medicine Departments through direct nuclear reactions induced by protons accelerated by compact medical cyclotrons on liquid or gaseous targets. Messina University has funded the construction of a PET-cyclotron-radio-chemistry plant at the Messina University Hospital, equipped with a 11 MeV self-shielded cyclotron. We estimated the expected production yields of these nuclides, accounting for target thickness, production of other radioactive nuclides, and time effects on the irradiated target purity. To this aim, both TALYS code (v. 1.8) and an analytical approach based on EXFOR experimental data were used. The general agreement between the two approaches, and with the available literature data, allows to assess the expected yields at the End of Bombardment, and relative target purities, to be used for further radiopharmaceutical preparation steps. |
url |
http://dx.doi.org/10.1478/AAPP.951A1
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