Vitamin E Supplementation, Lung Functions and Clinical Manifestations in Children with Moderate Asthma: A Randomized Double Blind Placebo- Controlled Trial

• Main Authors: Javad Ghaffari, Reza Farid Hossiani, Alireza Khalilian, Negin Nahanmoghadam, Ebrahim Salehifar, Houshang Rafatpanah
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2014-04-01
• Series: Iranian Journal of Allergy, Asthma and Immunology
• Subjects: Asthma; Child; Dietory supplements; Respiratory function tests; Vitamins; Vitamin E
• Online Access: https://ijaai.tums.ac.ir/index.php/ijaai/article/view/470
• ISSN: 1735-1502; 1735-5249

Asthma is the most  common  chronic inflammatory disorder characterized by cough, wheezing and dyspnea in children. Nutrition  is an important  factor which influences on induction and exacerbation of asthma. There are controversies to use Vitamin E in asthmatic patients. The aim of this study was to evaluate the effect of vitamin E supplement in children with moderate asthma. This is a randomized double blind placebo-controlled trial performed on children (age 2-17 years old) with moderate asthma (5-17 years old) from March 2010 to March 2012. Case group were treated with fluticasone and vitamin E (50mg/day) and control group received fluticasone plus placebo for 8 weeks. Out of 300 cases, 240 cases completed the study. Female to male ratio was 0.84. Serum level of Vitamin E significantly increased after treatment in intervention group. FEV1 and FEV1/FVC ratio was ignificantly improved in case group compared to the control group. It can be concluded that vitamin E supplement could improve clinical manifestations and pulmonary function test in children with moderate asthma.