Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells as well as CD4+ and CD8+ T cells. Patients with clinically significant im...

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Bibliographic Details
Main Authors: Elissa K. Deenick, Simon J. Pelham, Alisa Kane, Cindy S. Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
signal transducer and activator of transcription 3
T cells
B cells
immunodeficiency
immune dysregulation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00168/full
Description
Summary:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells as well as CD4+ and CD8+ T cells. Patients with clinically significant immunodeficiency and immune dysregulation resulting from loss-of-function or gain-of-function mutations in STAT3 have been described. These individuals provide insight into the critical role of this transcription factor in the regulation of immune responses and the balance between effective immune protection and autoimmunity.
ISSN:1664-3224

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