Variation rs2235503 C > A Within the Promoter of MSLN Affects Transcriptional Rate of Mesothelin and Plasmatic Levels of the Soluble Mesothelin-Related Peptide

Variation rs2235503 C > A Within the Promoter of MSLN Affects Transcriptional Rate of Mesothelin and Plasmatic Levels of the Soluble Mesothelin-Related Peptide

Soluble mesothelin-related peptide (SMRP) is a promising biomarker for malignant pleural mesothelioma (MPM), but several confounding factors can reduce SMRP-based test’s accuracy. The identification of these confounders could improve the diagnostic performance of SMRP. In this study, we evaluated th...

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Bibliographic Details
Main Authors: Roberto Silvestri, Perla Pucci, Chiara De Santi, Irene Dell’Anno, Simona Miglietta, Alda Corrado, Vanessa Nicolí, Daniela Marolda, Monica Cipollini, Enrica Pellegrino, Monica Evangelista, Alessandra Bonotti, Rudy Foddis, Alfonso Cristaudo, Stefano Landi, Federica Gemignani
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Genetics
Subjects:
soluble mesothelin-related peptide
malignant pleural mesothelioma
diagnostic biomarkers
single nucleotide polymorphisms
fluorescent reporter assay
eQTL
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00975/full

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