Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study
Abstract Background Individuals with high bone mass (HBM) have a greater odds of prevalent radiographic hip osteoarthritis (OA), reflecting an association with bone-forming OA sub-phenotypes (e.g. osteophytosis, subchondral sclerosis). As the role of bone mineral density (BMD) in hip OA progression...
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doaj-fa26c29b1def47f5a50e155f004b9a712021-01-10T13:00:56ZengBMCArthritis Research & Therapy1478-63622021-01-0123111210.1186/s13075-020-02371-0Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort studyApril Hartley0Sarah A. Hardcastle1Monika Frysz2Jon Parkinson3Lavinia Paternoster4Eugene McCloskey5Kenneth E. S. Poole6Muhammad K. Javaid7Mo Aye8Katie Moss9Martin Williams10Jon H. Tobias11Celia L. Gregson12Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of BristolMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of BristolMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of BristolDivision of Informatics, Imaging & Data Sciences, Faculty of Medical and Human Sciences, University of ManchesterMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of BristolAcademic Unit of Bone Metabolism, Department of Oncology and Metabolism, The Mellanby Centre For Bone Research, University of SheffieldCambridge NIHR Biomedical Research Centre and the Wellcome Trust Clinical Research FacilityNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of OxfordDepartment of Diabetes, Endocrinology and Metabolism, Hull and East Yorkshire Hospitals NHS TrustCentre for Rheumatology, St George’s Hospital, St George’s Healthcare NHS TrustDepartment of Radiology, Southmead Hospital, North Bristol NHS TrustMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of BristolMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of BristolAbstract Background Individuals with high bone mass (HBM) have a greater odds of prevalent radiographic hip osteoarthritis (OA), reflecting an association with bone-forming OA sub-phenotypes (e.g. osteophytosis, subchondral sclerosis). As the role of bone mineral density (BMD) in hip OA progression is unclear, we aimed to determine if individuals with HBM have increased incidence and/or progression of bone-forming OA sub-phenotypes. Methods We analysed an adult cohort with and without HBM (L1 and/or total hip BMD Z-score > + 3.2) with pelvic radiographs collected at baseline and 8-year follow-up. Sub-phenotypes were graded using the OARSI atlas. Superior/inferior acetabular/femoral osteophyte and medial/superior joint space narrowing (JSN) grades were summed and Δosteophyte and ΔJSN derived. Pain and functional limitations were quantified using the WOMAC questionnaire. Associations between HBM status and change in OA sub-phenotypes were determined using multivariable linear/logistic regression, adjusting for age, sex, height, total body fat mass, follow-up time and baseline sub-phenotype grade. Generalised estimating equations accounted for individual-level clustering. Results Of 136 individuals, 62% had HBM at baseline, 72% were female and mean (SD) age was 59 (10) years. HBM was positively associated with both Δosteophytes and ΔJSN (adjusted mean grade differences between individuals with and without HBM β osteophyte = 0.30 [0.01, 0.58], p = 0.019 and β JSN = 0.10 [0.01, 0.18], p = 0.019). Incident subchondral sclerosis was rare. HBM individuals had higher WOMAC hip functional limitation scores (β = 8.3 [0.7, 15.98], p = 0.032). Conclusions HBM is associated with the worsening of hip osteophytes and JSN over an average of 8 years, as well as increased hip pain and functional limitation.https://doi.org/10.1186/s13075-020-02371-0Hip osteoarthritisProgressionHigh bone massBMDWOMAC |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
April Hartley Sarah A. Hardcastle Monika Frysz Jon Parkinson Lavinia Paternoster Eugene McCloskey Kenneth E. S. Poole Muhammad K. Javaid Mo Aye Katie Moss Martin Williams Jon H. Tobias Celia L. Gregson |
spellingShingle |
April Hartley Sarah A. Hardcastle Monika Frysz Jon Parkinson Lavinia Paternoster Eugene McCloskey Kenneth E. S. Poole Muhammad K. Javaid Mo Aye Katie Moss Martin Williams Jon H. Tobias Celia L. Gregson Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study Arthritis Research & Therapy Hip osteoarthritis Progression High bone mass BMD WOMAC |
author_facet |
April Hartley Sarah A. Hardcastle Monika Frysz Jon Parkinson Lavinia Paternoster Eugene McCloskey Kenneth E. S. Poole Muhammad K. Javaid Mo Aye Katie Moss Martin Williams Jon H. Tobias Celia L. Gregson |
author_sort |
April Hartley |
title |
Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study |
title_short |
Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study |
title_full |
Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study |
title_fullStr |
Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study |
title_full_unstemmed |
Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study |
title_sort |
increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2021-01-01 |
description |
Abstract Background Individuals with high bone mass (HBM) have a greater odds of prevalent radiographic hip osteoarthritis (OA), reflecting an association with bone-forming OA sub-phenotypes (e.g. osteophytosis, subchondral sclerosis). As the role of bone mineral density (BMD) in hip OA progression is unclear, we aimed to determine if individuals with HBM have increased incidence and/or progression of bone-forming OA sub-phenotypes. Methods We analysed an adult cohort with and without HBM (L1 and/or total hip BMD Z-score > + 3.2) with pelvic radiographs collected at baseline and 8-year follow-up. Sub-phenotypes were graded using the OARSI atlas. Superior/inferior acetabular/femoral osteophyte and medial/superior joint space narrowing (JSN) grades were summed and Δosteophyte and ΔJSN derived. Pain and functional limitations were quantified using the WOMAC questionnaire. Associations between HBM status and change in OA sub-phenotypes were determined using multivariable linear/logistic regression, adjusting for age, sex, height, total body fat mass, follow-up time and baseline sub-phenotype grade. Generalised estimating equations accounted for individual-level clustering. Results Of 136 individuals, 62% had HBM at baseline, 72% were female and mean (SD) age was 59 (10) years. HBM was positively associated with both Δosteophytes and ΔJSN (adjusted mean grade differences between individuals with and without HBM β osteophyte = 0.30 [0.01, 0.58], p = 0.019 and β JSN = 0.10 [0.01, 0.18], p = 0.019). Incident subchondral sclerosis was rare. HBM individuals had higher WOMAC hip functional limitation scores (β = 8.3 [0.7, 15.98], p = 0.032). Conclusions HBM is associated with the worsening of hip osteophytes and JSN over an average of 8 years, as well as increased hip pain and functional limitation. |
topic |
Hip osteoarthritis Progression High bone mass BMD WOMAC |
url |
https://doi.org/10.1186/s13075-020-02371-0 |
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