Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities
The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute mo...
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doaj-fa2f37e2dad1460aac52b836b7ad57892020-11-24T20:44:35ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-01-0117214910.3390/ijms17020149ijms17020149Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal ActivitiesFernando Pereira Beserra0Raquel de Cássia Santos1Larissa Lucena Périco2Vinicius Peixoto Rodrigues3Luiz Ricardo de Almeida Kiguti4Luiz Leonardo Saldanha5André Sampaio Pupo6Lúcia Regina Machado da Rocha7Anne Lígia Dokkedal8Wagner Vilegas9Clélia Akiko Hiruma-Lima10Departamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, BrazilUnidade Integrada de Farmacologia e Gastroenterologia, Faculdade de Ciências Médicas, Universidade São Francisco, CEP 12916-900 Bragança Paulista, São Paulo, BrazilDepartamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, BrazilDepartamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, BrazilDepartamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, BrazilDepartamento de Ciências Biológicas, Faculdade de Ciências, Universidade Estadual Paulista—UNESP, CEP 17033-360 Bauru, São Paulo, BrazilDepartamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, BrazilDepartamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, BrazilDepartamento de Ciências Biológicas, Faculdade de Ciências, Universidade Estadual Paulista—UNESP, CEP 17033-360 Bauru, São Paulo, BrazilCampus Experimental do Litoral Paulista, Universidade Estadual Paulista-UNESP, CEP 11330-900 São Vicente, São Paulo, BrazilDepartamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, BrazilThe objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smooth muscle and/or intestinal transit.http://www.mdpi.com/1422-0067/17/2/149Cissus sicyoidesVitaceaeanti-inflammatoryPGE2antidiarrheal |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fernando Pereira Beserra Raquel de Cássia Santos Larissa Lucena Périco Vinicius Peixoto Rodrigues Luiz Ricardo de Almeida Kiguti Luiz Leonardo Saldanha André Sampaio Pupo Lúcia Regina Machado da Rocha Anne Lígia Dokkedal Wagner Vilegas Clélia Akiko Hiruma-Lima |
spellingShingle |
Fernando Pereira Beserra Raquel de Cássia Santos Larissa Lucena Périco Vinicius Peixoto Rodrigues Luiz Ricardo de Almeida Kiguti Luiz Leonardo Saldanha André Sampaio Pupo Lúcia Regina Machado da Rocha Anne Lígia Dokkedal Wagner Vilegas Clélia Akiko Hiruma-Lima Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities International Journal of Molecular Sciences Cissus sicyoides Vitaceae anti-inflammatory PGE2 antidiarrheal |
author_facet |
Fernando Pereira Beserra Raquel de Cássia Santos Larissa Lucena Périco Vinicius Peixoto Rodrigues Luiz Ricardo de Almeida Kiguti Luiz Leonardo Saldanha André Sampaio Pupo Lúcia Regina Machado da Rocha Anne Lígia Dokkedal Wagner Vilegas Clélia Akiko Hiruma-Lima |
author_sort |
Fernando Pereira Beserra |
title |
Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities |
title_short |
Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities |
title_full |
Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities |
title_fullStr |
Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities |
title_full_unstemmed |
Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities |
title_sort |
cissus sicyoides: pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2016-01-01 |
description |
The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smooth muscle and/or intestinal transit. |
topic |
Cissus sicyoides Vitaceae anti-inflammatory PGE2 antidiarrheal |
url |
http://www.mdpi.com/1422-0067/17/2/149 |
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