The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review
The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular disease have been studied extensively. However, it remains unclear to what extent n-3 PUFAs may impact Reverse Cholesterol Transport (RCT). RCT describes a mechanism by which excess cholesterol from periphera...
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doaj-fa3d21feb9dc4f04bfa4e829e5c0f6f12020-11-24T23:30:14ZengMDPI AGNutrients2072-66432017-10-01910109910.3390/nu9101099nu9101099The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A ReviewAlex Pizzini0Lukas Lunger1Egon Demetz2Richard Hilbe3Guenter Weiss4Christoph Ebenbichler5Ivan Tancevski6Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaThe beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular disease have been studied extensively. However, it remains unclear to what extent n-3 PUFAs may impact Reverse Cholesterol Transport (RCT). RCT describes a mechanism by which excess cholesterol from peripheral tissues is transported to the liver for hepatobiliary excretion, thereby inhibiting foam cell formation and the development of atherosclerosis. The aim of this review is to summarize the literature and to provide an updated overview of the effects of n-3 PUFAs on key players in RCT, including apoliprotein AI (apoA-I), ATP-binding cassette transporter A1 (ABCA1), ABCG1, apoE, scavenger receptor class B type I (SR-BI), cholesteryl ester transfer protein (CETP), low-density lipoprotein receptor (LDLr), cholesterol 7 alpha-hydroxylase (CYP7A1) and ABCG5/G8. Based on current knowledge, we conclude that n-3 PUFAs may beneficially affect RCT, mainly by influencing high-density lipoprotein (HDL) remodeling and by promoting hepatobiliary sterol excretion.https://www.mdpi.com/2072-6643/9/10/1099Omega 3PUFAn3-PUFARCTReverse Cholesterol Transport |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alex Pizzini Lukas Lunger Egon Demetz Richard Hilbe Guenter Weiss Christoph Ebenbichler Ivan Tancevski |
spellingShingle |
Alex Pizzini Lukas Lunger Egon Demetz Richard Hilbe Guenter Weiss Christoph Ebenbichler Ivan Tancevski The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review Nutrients Omega 3 PUFA n3-PUFA RCT Reverse Cholesterol Transport |
author_facet |
Alex Pizzini Lukas Lunger Egon Demetz Richard Hilbe Guenter Weiss Christoph Ebenbichler Ivan Tancevski |
author_sort |
Alex Pizzini |
title |
The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review |
title_short |
The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review |
title_full |
The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review |
title_fullStr |
The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review |
title_full_unstemmed |
The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review |
title_sort |
role of omega-3 fatty acids in reverse cholesterol transport: a review |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2017-10-01 |
description |
The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular disease have been studied extensively. However, it remains unclear to what extent n-3 PUFAs may impact Reverse Cholesterol Transport (RCT). RCT describes a mechanism by which excess cholesterol from peripheral tissues is transported to the liver for hepatobiliary excretion, thereby inhibiting foam cell formation and the development of atherosclerosis. The aim of this review is to summarize the literature and to provide an updated overview of the effects of n-3 PUFAs on key players in RCT, including apoliprotein AI (apoA-I), ATP-binding cassette transporter A1 (ABCA1), ABCG1, apoE, scavenger receptor class B type I (SR-BI), cholesteryl ester transfer protein (CETP), low-density lipoprotein receptor (LDLr), cholesterol 7 alpha-hydroxylase (CYP7A1) and ABCG5/G8. Based on current knowledge, we conclude that n-3 PUFAs may beneficially affect RCT, mainly by influencing high-density lipoprotein (HDL) remodeling and by promoting hepatobiliary sterol excretion. |
topic |
Omega 3 PUFA n3-PUFA RCT Reverse Cholesterol Transport |
url |
https://www.mdpi.com/2072-6643/9/10/1099 |
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