Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice

Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice

N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action that involves the activation of Ca2+ dependent signaling pathways. Moreover, ketamine, a global NMDAR antagonist is a potent, novel, and atypica...

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Main Authors: Bartłomiej Pochwat, Bernadeta Szewczyk, Katarzyna Kotarska, Anna Rafało-Ulińska, Marcin Siwiec, Joanna E. Sowa, Krzysztof Tokarski, Agata Siwek, Alexandre Bouron, Kristina Friedland, Gabriel Nowak
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
depression
NMDA - receptor
hyperforin
lanicemine
TRPC 6
ketamine
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00456/full

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