Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis
Avian infectious bronchitis (IB) is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines...
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doaj-fa5ec9671ca04bbf84e6e2781166cea92020-11-24T23:53:40ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/424860424860Progress and Challenges toward the Development of Vaccines against Avian Infectious BronchitisFaruku Bande0Siti Suri Arshad1Mohd Hair Bejo2Hassan Moeini3Abdul Rahman Omar4Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaDepartment of Virus-Associated Tumours (F100), German Cancer Research Centre, Im Neuenheimer Feld 242, 69120 Heidelberg, GermanyDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaAvian infectious bronchitis (IB) is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage. On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens. Consequently, alternative IB vaccines are widely sought. Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines. Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches. Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes.http://dx.doi.org/10.1155/2015/424860 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Faruku Bande Siti Suri Arshad Mohd Hair Bejo Hassan Moeini Abdul Rahman Omar |
spellingShingle |
Faruku Bande Siti Suri Arshad Mohd Hair Bejo Hassan Moeini Abdul Rahman Omar Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis Journal of Immunology Research |
author_facet |
Faruku Bande Siti Suri Arshad Mohd Hair Bejo Hassan Moeini Abdul Rahman Omar |
author_sort |
Faruku Bande |
title |
Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis |
title_short |
Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis |
title_full |
Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis |
title_fullStr |
Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis |
title_full_unstemmed |
Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis |
title_sort |
progress and challenges toward the development of vaccines against avian infectious bronchitis |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2015-01-01 |
description |
Avian infectious bronchitis (IB) is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage. On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens. Consequently, alternative IB vaccines are widely sought. Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines. Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches. Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes. |
url |
http://dx.doi.org/10.1155/2015/424860 |
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