Directing curli polymerization with DNA origami nucleators
Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and subsequent fibrillization of CsgA proteins.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09369-6 |
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Article |
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doaj-fa62fc4764634a9b9fded575c3944a522021-05-11T11:41:16ZengNature Publishing GroupNature Communications2041-17232019-03-0110111010.1038/s41467-019-09369-6Directing curli polymerization with DNA origami nucleatorsXiuhai Mao0Ke Li1Mengmeng Liu2Xinyu Wang3Tianxin Zhao4Bolin An5Mengkui Cui6Yingfeng Li7Jiahua Pu8Jiang Li9Lihua Wang10Timothy K. Lu11Chunhai Fan12Chao Zhong13Materials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityMaterials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal UniversityMaterials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityMaterials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityMaterials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityMaterials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityMaterials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityMaterials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityDivision of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of SciencesDivision of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of SciencesSynthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of TechnologySchool of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityMaterials and Physical Biology Division, School of Physical Science and Technology, ShanghaiTech UniversityCurli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and subsequent fibrillization of CsgA proteins.https://doi.org/10.1038/s41467-019-09369-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiuhai Mao Ke Li Mengmeng Liu Xinyu Wang Tianxin Zhao Bolin An Mengkui Cui Yingfeng Li Jiahua Pu Jiang Li Lihua Wang Timothy K. Lu Chunhai Fan Chao Zhong |
| spellingShingle |
Xiuhai Mao Ke Li Mengmeng Liu Xinyu Wang Tianxin Zhao Bolin An Mengkui Cui Yingfeng Li Jiahua Pu Jiang Li Lihua Wang Timothy K. Lu Chunhai Fan Chao Zhong Directing curli polymerization with DNA origami nucleators Nature Communications |
| author_facet |
Xiuhai Mao Ke Li Mengmeng Liu Xinyu Wang Tianxin Zhao Bolin An Mengkui Cui Yingfeng Li Jiahua Pu Jiang Li Lihua Wang Timothy K. Lu Chunhai Fan Chao Zhong |
| author_sort |
Xiuhai Mao |
| title |
Directing curli polymerization with DNA origami nucleators |
| title_short |
Directing curli polymerization with DNA origami nucleators |
| title_full |
Directing curli polymerization with DNA origami nucleators |
| title_fullStr |
Directing curli polymerization with DNA origami nucleators |
| title_full_unstemmed |
Directing curli polymerization with DNA origami nucleators |
| title_sort |
directing curli polymerization with dna origami nucleators |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-03-01 |
| description |
Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and subsequent fibrillization of CsgA proteins. |
| url |
https://doi.org/10.1038/s41467-019-09369-6 |
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