Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease with no effective therapy available. We recorded spontaneous magnetoencephalography and auditory evoked fields (AEFs) from a male patient with a rapidly progressive memory disorder, ataxia and myoclonus. Post-mortem examination conf...
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doaj-fa6584fd0de1462db86069a7e4429df12020-11-24T20:53:53ZengKarger PublishersCase Reports in Neurology1662-680X2010-10-012312212710.1159/000321349321349Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case ReportJuha WileniusJyrki P. MäkeläJukka LyytinenAnders PaetauMaarit PalomäkiEero PekkonenCreutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease with no effective therapy available. We recorded spontaneous magnetoencephalography and auditory evoked fields (AEFs) from a male patient with a rapidly progressive memory disorder, ataxia and myoclonus. Post-mortem examination confirmed sporadic CJD. Sources of the abnormal slow wave activity were localized with a beamformer software. Sources of sharp transients and AEFs were modeled with equivalent current dipoles. The estimated sources of spontaneous activity abnormalities were more dominant in the left hemisphere, in line with left-dominant abnormalities in diffusion-weighted MRI. Sources of AEFs were found in both temporal lobes. Magnetoencephalography measurements on CJD patients are feasible, and provide efficient means for localizing abnormal cortical activity in CJD.http://www.karger.com/Article/FullText/321349Creutzfeldt-Jakob diseasePrion diseaseTransmissible spongiform encephalopathyMagnetoencephalography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juha Wilenius Jyrki P. Mäkelä Jukka Lyytinen Anders Paetau Maarit Palomäki Eero Pekkonen |
spellingShingle |
Juha Wilenius Jyrki P. Mäkelä Jukka Lyytinen Anders Paetau Maarit Palomäki Eero Pekkonen Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report Case Reports in Neurology Creutzfeldt-Jakob disease Prion disease Transmissible spongiform encephalopathy Magnetoencephalography |
author_facet |
Juha Wilenius Jyrki P. Mäkelä Jukka Lyytinen Anders Paetau Maarit Palomäki Eero Pekkonen |
author_sort |
Juha Wilenius |
title |
Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report |
title_short |
Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report |
title_full |
Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report |
title_fullStr |
Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report |
title_full_unstemmed |
Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report |
title_sort |
magnetoencephalographic abnormalities in creutzfeldt-jakob disease: a case report |
publisher |
Karger Publishers |
series |
Case Reports in Neurology |
issn |
1662-680X |
publishDate |
2010-10-01 |
description |
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease with no effective therapy available. We recorded spontaneous magnetoencephalography and auditory evoked fields (AEFs) from a male patient with a rapidly progressive memory disorder, ataxia and myoclonus. Post-mortem examination confirmed sporadic CJD. Sources of the abnormal slow wave activity were localized with a beamformer software. Sources of sharp transients and AEFs were modeled with equivalent current dipoles. The estimated sources of spontaneous activity abnormalities were more dominant in the left hemisphere, in line with left-dominant abnormalities in diffusion-weighted MRI. Sources of AEFs were found in both temporal lobes. Magnetoencephalography measurements on CJD patients are feasible, and provide efficient means for localizing abnormal cortical activity in CJD. |
topic |
Creutzfeldt-Jakob disease Prion disease Transmissible spongiform encephalopathy Magnetoencephalography |
url |
http://www.karger.com/Article/FullText/321349 |
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