Circulating Methylated DNA to Monitor the Dynamics of RAS Mutation Clearance in Plasma from Metastatic Colorectal Cancer Patients

Circulating Methylated DNA to Monitor the Dynamics of RAS Mutation Clearance in Plasma from Metastatic Colorectal Cancer Patients

The clearance of RAS mutations in plasma circulating tumor DNA (ctDNA) from originally RAS-mutant metastatic colorectal cancer (mCRC) has been recently demonstrated. Clinical trials investigating whether RAS mutant mCRC who “convert” to wild-type in plasma might benefit from EGFR blockade are ongoin...

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Bibliographic Details
Main Authors: Chiara Nicolazzo, Ludovic Barault, Salvatore Caponnetto, Marco Macagno, Gianluigi De Renzi, Angela Gradilone, Francesca Belardinilli, Enrico Cortesi, Federica Di Nicolantonio, Paola Gazzaniga
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
circulating methylated DNA
circulating tumor DNA
EGFR inhibitors
liquid biopsy
metastatic colorectal cancer
RAS mutation clearance
Online Access:https://www.mdpi.com/2072-6694/12/12/3633

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