A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.
<h4>Background</h4>Many computed tomography (CT) studies have reported that lipid-rich, presumably rupture-prone atherosclerotic plaques can be characterized according to their Hounsfield Unit (HU) value. However, the published HU-based characterization criteria vary considerably. The pr...
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doaj-fa6decbca4474c91ad9ee0a7886fa6c52021-03-03T22:56:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7346010.1371/journal.pone.0073460A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.Wisnumurti KristantoPeter M A van OoijenMarijke C Jansen-van der WeideRozemarijn VliegenthartMatthijs Oudkerk<h4>Background</h4>Many computed tomography (CT) studies have reported that lipid-rich, presumably rupture-prone atherosclerotic plaques can be characterized according to their Hounsfield Unit (HU) value. However, the published HU-based characterization criteria vary considerably. The present study aims to systematically analyze these values and empirically derive a hierarchical classification of the HU-based criteria which can be referred in clinical situation.<h4>Material and methods</h4>A systematic search in PubMed and Embase for publications with HU-criteria to characterize lipid-rich and fibrous atherosclerotic plaques resulted in 36 publications, published between 1998 and 2011. The HU-criteria were systematically analyzed based on the characteristics of the reporting study. Significant differences between HU-criteria were checked using Student's t-test. Subsequently, a hierarchical classification of HU-criteria was developed based on the respective study characteristics.<h4>Results</h4>No correlation was found between HU-criteria and the reported lumen contrast-enhancement. Significant differences were found for HU-criteria when pooled according to the respective study characteristics: examination type, vessel type, CT-vendor, detector-rows, voltage-setting, and collimation-width. The hierarchical classification resulted in 21 and 22 CT attenuation value categories, for lipid-rich and fibrous plaque, respectively. More than 50% of the hierarchically classified HU-criteria were significantly different.<h4>Conclusion</h4>In conclusion, variations in the reported CT attenuation values for lipid-rich and fibrous plaque are so large that generalized values are unreliable for clinical use. The proposed hierarchical classification can be used to determine reference CT attenuation values of lipid-rich and fibrous plaques for the local setting.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24019924/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wisnumurti Kristanto Peter M A van Ooijen Marijke C Jansen-van der Weide Rozemarijn Vliegenthart Matthijs Oudkerk |
spellingShingle |
Wisnumurti Kristanto Peter M A van Ooijen Marijke C Jansen-van der Weide Rozemarijn Vliegenthart Matthijs Oudkerk A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria. PLoS ONE |
author_facet |
Wisnumurti Kristanto Peter M A van Ooijen Marijke C Jansen-van der Weide Rozemarijn Vliegenthart Matthijs Oudkerk |
author_sort |
Wisnumurti Kristanto |
title |
A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria. |
title_short |
A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria. |
title_full |
A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria. |
title_fullStr |
A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria. |
title_full_unstemmed |
A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria. |
title_sort |
meta analysis and hierarchical classification of hu-based atherosclerotic plaque characterization criteria. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
<h4>Background</h4>Many computed tomography (CT) studies have reported that lipid-rich, presumably rupture-prone atherosclerotic plaques can be characterized according to their Hounsfield Unit (HU) value. However, the published HU-based characterization criteria vary considerably. The present study aims to systematically analyze these values and empirically derive a hierarchical classification of the HU-based criteria which can be referred in clinical situation.<h4>Material and methods</h4>A systematic search in PubMed and Embase for publications with HU-criteria to characterize lipid-rich and fibrous atherosclerotic plaques resulted in 36 publications, published between 1998 and 2011. The HU-criteria were systematically analyzed based on the characteristics of the reporting study. Significant differences between HU-criteria were checked using Student's t-test. Subsequently, a hierarchical classification of HU-criteria was developed based on the respective study characteristics.<h4>Results</h4>No correlation was found between HU-criteria and the reported lumen contrast-enhancement. Significant differences were found for HU-criteria when pooled according to the respective study characteristics: examination type, vessel type, CT-vendor, detector-rows, voltage-setting, and collimation-width. The hierarchical classification resulted in 21 and 22 CT attenuation value categories, for lipid-rich and fibrous plaque, respectively. More than 50% of the hierarchically classified HU-criteria were significantly different.<h4>Conclusion</h4>In conclusion, variations in the reported CT attenuation values for lipid-rich and fibrous plaque are so large that generalized values are unreliable for clinical use. The proposed hierarchical classification can be used to determine reference CT attenuation values of lipid-rich and fibrous plaques for the local setting. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24019924/?tool=EBI |
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