Synthesis and Biological Evaluation of Novel 99mTc-Labelled Bisphosphonates as Superior Bone Imaging Agents

Synthesis and Biological Evaluation of Novel 99mTc-Labelled Bisphosphonates as Superior Bone Imaging Agents

A series of novel zoledronic acid (ZL) derivatives 1-hydroxy-3-(2-methyl-1H-imidazol-1-yl)propane-1,1-diyldiphosphonic acid (MIPrDP), 1-hydroxy-4-(2-methyl-1H-imidazol-1-yl)butane-1,1-diyldiphosphonic acid (MIBDP), and 1-hydroxy-5-(2-methyl-1H-imidazol-1-yl)pentane-1,1-diyldiphosphonic acid (MIPeDP)...

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Bibliographic Details
Main Authors: Shineng Luo, Li Xue, Jing Pan, Ling Qiu, Wen Cheng, Jianguo Lin
Format: Article
Language:English
Published: MDPI AG 2011-07-01
Series:Molecules
Subjects:
zoledronic acid derivative
99mTc-labelled diphosphonates
in vitro stability
biodistribution
bone imaging agent
Online Access:http://www.mdpi.com/1420-3049/16/8/6165/

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http://www.mdpi.com/1420-3049/16/8/6165/

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