Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models.

Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models.

Inactivated orf virus (iORFV), strain D1701, is a potent immune modulator in various animal species. We recently demonstrated that iORFV induces strong antiviral activity in animal models of acute and chronic viral infections. In addition, we found D1701-mediated antifibrotic effects in different ra...

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Main Authors: Daniela Paulsen, Andreas Urban, Andreas Knorr, Claudia Hirth-Dietrich, Angela Siegling, Hans-Dieter Volk, Andrew A Mercer, Andreas Limmer, Beatrix Schumak, Percy Knolle, Helga Ruebsamen-Schaeff, Olaf Weber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3774719?pdf=render

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