Effects of glomerular filtration rate on the severity of coronary heart disease
Objective: Chronic kidney disease (CKD) is considered to be one of the most common risk factors for cardiovascular diseases. Glomerular filtration rate (GFR) is the best method of testing level of kidney function and determining stage of kidney disease. The aim of this study was to examine the impa...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
KARE Publishing
2016-04-01
|
Series: | Türk Kardiyoloji Derneği Arşivi |
Subjects: | |
Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-48323 |
id |
doaj-fa713f83d74847aaa0cf2d98d642d9f6 |
---|---|
record_format |
Article |
spelling |
doaj-fa713f83d74847aaa0cf2d98d642d9f62021-01-19T07:41:19ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692016-04-0144212312910.5543/tkda.2015.48323TKDA-48323Effects of glomerular filtration rate on the severity of coronary heart diseaseBerkay Ekici0Aslı Tanındı1Irmak Sayın2Department of Cardiology, Ufuk University Faculty of Medicine, Ankara, TurkeyDepartment of Cardiology, Ufuk University Faculty of Medicine, Ankara, TurkeyDepartment of Internal Medicine, Ufuk University Faculty of Medicine, Ankara, TurkeyObjective: Chronic kidney disease (CKD) is considered to be one of the most common risk factors for cardiovascular diseases. Glomerular filtration rate (GFR) is the best method of testing level of kidney function and determining stage of kidney disease. The aim of this study was to examine the impact of renal function on severity of coronary heart disease (CHD). Methods: The present study included 918 patients undergoing elective coronary angiography. GFR was evaluated by simplified Modification of Diet in Renal Disease (MDRD) formula (mL/min/1.73 m2). The extent and severity of CHD were evaluated according to SYNTAX score. Results: According to SYNTAX score, 416 patients had normal coronary arteries or nonsignificant CHD (control group), 267 had mild CHD (SYNTAX score: 1–22), 129 had moderate CHD (SYNTAX score: 23–32), and 106 had severe CHD (SYNTAX score: ≥33). Estimated GFR values (median [25th– 75th percentiles]) were 99.00 (83.00–116.00) in the control group, 85.00 (73.00–101.00) in the mild CHD group, 87.00 (73.25–101.75) in the moderate CHD group, and 81.00 (65.00–101.00) in the severe CHD group. According to Spearman's rank correlation analysis, a negative correlation found between MDRD and SYNTAX score was statistically significant (p<0.001, r=-0.268). Conclusion: Renal function is an important predictor of presence and severity of angiographic CHD in patients without severe renal impairment. Negative correlation between MDRD and SYNTAX score was determined. This simple biochemical test can be used in determining risk of cardiovascular disease aside from other risk factors during routine clinical practice.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-48323coronary artery diseaseglomerular filtration rate; kidney function; syntax score |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Berkay Ekici Aslı Tanındı Irmak Sayın |
spellingShingle |
Berkay Ekici Aslı Tanındı Irmak Sayın Effects of glomerular filtration rate on the severity of coronary heart disease Türk Kardiyoloji Derneği Arşivi coronary artery disease glomerular filtration rate; kidney function; syntax score |
author_facet |
Berkay Ekici Aslı Tanındı Irmak Sayın |
author_sort |
Berkay Ekici |
title |
Effects of glomerular filtration rate on the severity of coronary heart disease |
title_short |
Effects of glomerular filtration rate on the severity of coronary heart disease |
title_full |
Effects of glomerular filtration rate on the severity of coronary heart disease |
title_fullStr |
Effects of glomerular filtration rate on the severity of coronary heart disease |
title_full_unstemmed |
Effects of glomerular filtration rate on the severity of coronary heart disease |
title_sort |
effects of glomerular filtration rate on the severity of coronary heart disease |
publisher |
KARE Publishing |
series |
Türk Kardiyoloji Derneği Arşivi |
issn |
1016-5169 |
publishDate |
2016-04-01 |
description |
Objective: Chronic kidney disease (CKD) is considered to be one of the most common risk factors for cardiovascular diseases. Glomerular filtration rate (GFR) is the best method of testing level of kidney function and determining stage of kidney disease. The aim of this study was to examine the impact of renal function on severity of coronary heart disease (CHD).
Methods: The present study included 918 patients undergoing elective coronary angiography. GFR was evaluated by simplified Modification of Diet in Renal Disease (MDRD) formula (mL/min/1.73 m2). The extent and severity of CHD were evaluated according to SYNTAX score.
Results: According to SYNTAX score, 416 patients had normal coronary arteries or nonsignificant CHD (control group), 267 had mild CHD (SYNTAX score: 1–22), 129 had moderate CHD (SYNTAX score: 23–32), and 106 had severe CHD (SYNTAX score: ≥33). Estimated GFR values (median [25th– 75th percentiles]) were 99.00 (83.00–116.00) in the control group, 85.00 (73.00–101.00) in the mild CHD group, 87.00 (73.25–101.75) in the moderate CHD group, and 81.00 (65.00–101.00) in the severe CHD group. According to Spearman's rank correlation analysis, a negative correlation found between MDRD and SYNTAX score was statistically significant (p<0.001, r=-0.268).
Conclusion: Renal function is an important predictor of presence and severity of angiographic CHD in patients without severe renal impairment. Negative correlation between MDRD and SYNTAX score was determined. This simple biochemical test can be used in determining risk of cardiovascular disease aside from other risk factors during routine clinical practice. |
topic |
coronary artery disease glomerular filtration rate; kidney function; syntax score |
url |
https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-48323 |
work_keys_str_mv |
AT berkayekici effectsofglomerularfiltrationrateontheseverityofcoronaryheartdisease AT aslıtanındı effectsofglomerularfiltrationrateontheseverityofcoronaryheartdisease AT irmaksayın effectsofglomerularfiltrationrateontheseverityofcoronaryheartdisease |
_version_ |
1724332340852817920 |