Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically
Introduction: Blood vessel formation by angiogenesis is essential for goitre development. Angiopoietin 1 (Ang-1),angiopoietin 2 (Ang-2) and Tie-2 receptor (rTie-2) are involved in part of angiogenesis. Ang-1 and rTie-2 expressionincreases in goitre.Aim: To determine serum concentrations (SC) of angi...
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doaj-fa7907ffd81a4a259109a469e5ae7fd22020-11-24T23:20:10ZengTermedia Publishing HouseVideosurgery and Other Miniinvasive Techniques1895-45882011-06-01626472Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgicallyJoanna KalupaKrzysztof KuzdakKrzysztof KołomeckiIntroduction: Blood vessel formation by angiogenesis is essential for goitre development. Angiopoietin 1 (Ang-1),angiopoietin 2 (Ang-2) and Tie-2 receptor (rTie-2) are involved in part of angiogenesis. Ang-1 and rTie-2 expressionincreases in goitre.Aim: To determine serum concentrations (SC) of angiogenic cytokines of patients with goitre treated surgically.Material and mathods: Thirty-six patients with goitre aged 29-64 were examined. They were divided into groups: nontoxicnodular goitre (NTNG) and toxic goitre (TG). Each group was divided into subgroups: before and after surgery.The control group comprised 10 healthy subjects. Ang-1, Ang-2 and rTie-2 SC were measured in euthyroid subjects byELISA. Measurements were performed before the procedure and three months after.Results: Before surgery Ang-1 median (Me) SC in patients with TG was higher than in patients with NTNG (109 368pg/ml vs. 71 185 pg/ml) and in controls (109 368 pg/ml vs. 57 815 pg/ml). Ang-1 Me in TG patients was higher prior tothan after surgery (109 368 pg/ml vs. 65380 pg/ml). Ang-2 Me in TG patients was higher after than prior to surgery(4055 pg/ml vs. 3924 pg/ml). Significant correlations were found between Ang-1 and Tie-2 Me (r = 0.53) and Ang-2and Tie-2 (r = 0.58) in patients with NTNG before surgery and between Me Ang-2 and Tie-2 in patients with NTNGafter surgery (r = 0.89) and in controls (r = 0.77).Conclusions: Before surgery in patients with TG SC of Ang-1 was higher than in patients with NTNG and in controls.After surgery in patients with TG SC of Ang-1 decreased, and SC of Ang-2 increased. Significant correlations werefound between SC of Ang-2 and Tie-2 in patients with NTNG and in controls.http://www.termedia.pl/Original-paper-Assessment-of-peripheral-blood-concentration-of-angiopoietin-1-angiopoietin-2-and-Tie-2-a-tyrosine-kinase-receptor-of-patients-with-goitre-treated-surgically,42,16930,1,0.htmlangiogenesisangiopoietin 1angiopoietin 2Tie-2 receptorgoitre |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joanna Kalupa Krzysztof Kuzdak Krzysztof Kołomecki |
spellingShingle |
Joanna Kalupa Krzysztof Kuzdak Krzysztof Kołomecki Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically Videosurgery and Other Miniinvasive Techniques angiogenesis angiopoietin 1 angiopoietin 2 Tie-2 receptor goitre |
author_facet |
Joanna Kalupa Krzysztof Kuzdak Krzysztof Kołomecki |
author_sort |
Joanna Kalupa |
title |
Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically |
title_short |
Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically |
title_full |
Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically |
title_fullStr |
Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically |
title_full_unstemmed |
Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically |
title_sort |
assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically |
publisher |
Termedia Publishing House |
series |
Videosurgery and Other Miniinvasive Techniques |
issn |
1895-4588 |
publishDate |
2011-06-01 |
description |
Introduction: Blood vessel formation by angiogenesis is essential for goitre development. Angiopoietin 1 (Ang-1),angiopoietin 2 (Ang-2) and Tie-2 receptor (rTie-2) are involved in part of angiogenesis. Ang-1 and rTie-2 expressionincreases in goitre.Aim: To determine serum concentrations (SC) of angiogenic cytokines of patients with goitre treated surgically.Material and mathods: Thirty-six patients with goitre aged 29-64 were examined. They were divided into groups: nontoxicnodular goitre (NTNG) and toxic goitre (TG). Each group was divided into subgroups: before and after surgery.The control group comprised 10 healthy subjects. Ang-1, Ang-2 and rTie-2 SC were measured in euthyroid subjects byELISA. Measurements were performed before the procedure and three months after.Results: Before surgery Ang-1 median (Me) SC in patients with TG was higher than in patients with NTNG (109 368pg/ml vs. 71 185 pg/ml) and in controls (109 368 pg/ml vs. 57 815 pg/ml). Ang-1 Me in TG patients was higher prior tothan after surgery (109 368 pg/ml vs. 65380 pg/ml). Ang-2 Me in TG patients was higher after than prior to surgery(4055 pg/ml vs. 3924 pg/ml). Significant correlations were found between Ang-1 and Tie-2 Me (r = 0.53) and Ang-2and Tie-2 (r = 0.58) in patients with NTNG before surgery and between Me Ang-2 and Tie-2 in patients with NTNGafter surgery (r = 0.89) and in controls (r = 0.77).Conclusions: Before surgery in patients with TG SC of Ang-1 was higher than in patients with NTNG and in controls.After surgery in patients with TG SC of Ang-1 decreased, and SC of Ang-2 increased. Significant correlations werefound between SC of Ang-2 and Tie-2 in patients with NTNG and in controls. |
topic |
angiogenesis angiopoietin 1 angiopoietin 2 Tie-2 receptor goitre |
url |
http://www.termedia.pl/Original-paper-Assessment-of-peripheral-blood-concentration-of-angiopoietin-1-angiopoietin-2-and-Tie-2-a-tyrosine-kinase-receptor-of-patients-with-goitre-treated-surgically,42,16930,1,0.html |
work_keys_str_mv |
AT joannakalupa assessmentofperipheralbloodconcentrationofangiopoietin1angiopoietin2andtie2atyrosinekinasereceptorofpatientswithgoitretreatedsurgically AT krzysztofkuzdak assessmentofperipheralbloodconcentrationofangiopoietin1angiopoietin2andtie2atyrosinekinasereceptorofpatientswithgoitretreatedsurgically AT krzysztofkołomecki assessmentofperipheralbloodconcentrationofangiopoietin1angiopoietin2andtie2atyrosinekinasereceptorofpatientswithgoitretreatedsurgically |
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