The regulatory impact of RNA-binding proteins on microRNA targeting

miRNAs are loaded into Argonaute protein and repress complementary mRNA targets. Here the authors show the unappreciated role of RNA binding proteins for efficient miRNA targeting and expand the current understanding of miRNA targeting.

Bibliographic Details
Main Authors: Sukjun Kim, Soyoung Kim, Hee Ryung Chang, Doyeon Kim, Junehee Park, Narae Son, Joori Park, Minhyuk Yoon, Gwangung Chae, Young-Kook Kim, V. Narry Kim, Yoon Ki Kim, Jin-Wu Nam, Chanseok Shin, Daehyun Baek
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25078-5
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spelling doaj-fa80ba4bd3e24c5eae00608527853f852021-08-22T11:39:01ZengNature Publishing GroupNature Communications2041-17232021-08-0112111510.1038/s41467-021-25078-5The regulatory impact of RNA-binding proteins on microRNA targetingSukjun Kim0Soyoung Kim1Hee Ryung Chang2Doyeon Kim3Junehee Park4Narae Son5Joori Park6Minhyuk Yoon7Gwangung Chae8Young-Kook Kim9V. Narry Kim10Yoon Ki Kim11Jin-Wu Nam12Chanseok Shin13Daehyun Baek14School of Biological Sciences, Seoul National UniversityDepartment of Agricultural Biotechnology, Seoul National UniversitySchool of Biological Sciences, Seoul National UniversitySchool of Biological Sciences, Seoul National UniversitySchool of Biological Sciences, Seoul National UniversitySchool of Biological Sciences, Seoul National UniversityCreative Research Initiatives Center for Molecular Biology of Translation, Korea UniversityDepartment of Agricultural Biotechnology, Seoul National UniversityDepartment of Agricultural Biotechnology, Seoul National UniversityDepartment of Biochemistry, Chonnam National University Medical SchoolSchool of Biological Sciences, Seoul National UniversityCreative Research Initiatives Center for Molecular Biology of Translation, Korea UniversityDepartment of Life Science, College of Natural Sciences, Hanyang UniversityDepartment of Agricultural Biotechnology, Seoul National UniversitySchool of Biological Sciences, Seoul National UniversitymiRNAs are loaded into Argonaute protein and repress complementary mRNA targets. Here the authors show the unappreciated role of RNA binding proteins for efficient miRNA targeting and expand the current understanding of miRNA targeting.https://doi.org/10.1038/s41467-021-25078-5
collection DOAJ
language English
format Article
sources DOAJ
author Sukjun Kim
Soyoung Kim
Hee Ryung Chang
Doyeon Kim
Junehee Park
Narae Son
Joori Park
Minhyuk Yoon
Gwangung Chae
Young-Kook Kim
V. Narry Kim
Yoon Ki Kim
Jin-Wu Nam
Chanseok Shin
Daehyun Baek
spellingShingle Sukjun Kim
Soyoung Kim
Hee Ryung Chang
Doyeon Kim
Junehee Park
Narae Son
Joori Park
Minhyuk Yoon
Gwangung Chae
Young-Kook Kim
V. Narry Kim
Yoon Ki Kim
Jin-Wu Nam
Chanseok Shin
Daehyun Baek
The regulatory impact of RNA-binding proteins on microRNA targeting
Nature Communications
author_facet Sukjun Kim
Soyoung Kim
Hee Ryung Chang
Doyeon Kim
Junehee Park
Narae Son
Joori Park
Minhyuk Yoon
Gwangung Chae
Young-Kook Kim
V. Narry Kim
Yoon Ki Kim
Jin-Wu Nam
Chanseok Shin
Daehyun Baek
author_sort Sukjun Kim
title The regulatory impact of RNA-binding proteins on microRNA targeting
title_short The regulatory impact of RNA-binding proteins on microRNA targeting
title_full The regulatory impact of RNA-binding proteins on microRNA targeting
title_fullStr The regulatory impact of RNA-binding proteins on microRNA targeting
title_full_unstemmed The regulatory impact of RNA-binding proteins on microRNA targeting
title_sort regulatory impact of rna-binding proteins on microrna targeting
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-08-01
description miRNAs are loaded into Argonaute protein and repress complementary mRNA targets. Here the authors show the unappreciated role of RNA binding proteins for efficient miRNA targeting and expand the current understanding of miRNA targeting.
url https://doi.org/10.1038/s41467-021-25078-5
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