Aspirin resistance status as determined by urinary thromboxane B2 (TXB2) level in patients with ischemic heart disease and its relationship with Severity of coronary artery disease

• Main Authors: Naghmeh Ziaie, Masoomeh Sadeghi, Arash akhlaghi, Omid Pirhaji, Majid Yaran, Masood Pourmoghadas
• Format: Article
• Language: fas
• Published: Vesnu Publications 2011-01-01
• Series: مجله دانشکده پزشکی اصفهان
• Subjects: Aspirin resistance; Thromboxane B2 level; Coronary artery disease (CAD)
• Online Access: http://jims.mui.ac.ir/index.php/jims/article/view/558
• ISSN: 1027-7595; 1735-854X

Background: Coronary artery disease (CAD) and myocardial infarction are the most common cause of mortality and morbidity all over the world.. Aspirin resistance is an important part of therapeutic failure in patients who experience several atherosclerotic events despite aspirin therapy.Different stud-ies have reported aspirin resistance between 5-45% all over the world. According to different re-sponses to aspirin therapy in different countries and lack of adequate studies on aspirin resistance in Iran, this study was designed for invitro evaluation of aspirin resistance in Iranian patients . Methods: 170 patients with documented coronary artery stenosis were enrolled in this cross-sectional prospective study. 2 cc urine samples were obtained from all the subjects.Then a questionnaire includ-ing questions about ischemic heart disease risk factors (hypertension, diabetes, hyperlipidemia, obesity and smoking) was completed for each patient. Thromboxane B2 level in urine was measured two times for each patient via ELISA method. Data were analyzed via SPSS 16. with General Linear Model (Univariate).Gensini modified was used for assessment of severity of coronary arteries in-volvement (Coronary angiography score). Finding: 75.3% of studied patients were aspirin resistant. There was significant relationship between angiography score and aspirin resistance (Pvalue