Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional study
Abstract Background Antimicrobial agents are among the most commonly prescribed drugs in pregnancy due to the increased susceptibility to infections during pregnancy. Antimicrobials can contribute to different maternal complications. Therefore, it is important to study their patterns in prescription...
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doaj-fa931d2527ac4fa190eedb527ce5ae492021-01-17T12:23:22ZengBMCJournal of Pharmaceutical Policy and Practice2052-32112021-01-0114111010.1186/s40545-020-00292-6Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional studyMohamed A. Baraka0Lina Hussain AlLehaibi1Hind Nasser AlSuwaidan2Duaa Alsulaiman3Md. Ashraful Islam4Badriyah Shadid Alotaibi5Amany Alboghdadly6Ali H. Homoud7Fuad H. Al-Ghamdi8Mastour S. Al Ghamdi9Zaheer-Ud-Din Babar10Clinical Pharmacy Department, College of Pharmacy, Al Ain UniversityFirst Health Cluster in Eastern Province, Dammam Medical ComplexCollege of Clinical Pharmacy, Imam Abdulrahman Bin Faisal UniversityKing Fahd Hospital of the University (KFHU), Imam Abdulrahman Bin Faisal UniversityPharmacy Practice Department, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal UniversityDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman UniversityCollege of Pharmacy, Princess Nourah Bint Abdulrahman UniversityClinical Pharmacy Service, Johns Hopkins Aramco HealthcarePharmacy Department at Johns Hopkins Aramco HealthcareDepartment of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal UniversityDepartment of Pharmacy, School of Applied Sciences, University of HuddersfieldAbstract Background Antimicrobial agents are among the most commonly prescribed drugs in pregnancy due to the increased susceptibility to infections during pregnancy. Antimicrobials can contribute to different maternal complications. Therefore, it is important to study their patterns in prescription and utilization. The data regarding this issue is scarce in Saudi Arabia. Therefore, the aim of this study is to generate data on the antimicrobial agents that are most commonly prescribed during pregnancy as well as their indications and safety. Methods This is a retrospective study focusing on pregnant women with a known antimicrobial use at Johns Hopkins Aramco Healthcare (JHAH). The sample included 344 pregnant women with a total of 688 antimicrobial agents prescribed. Data was collected on the proportion of pregnant women who received antimicrobial agents and on the drug safety during pregnancy using the risk categorization system of the U.S. Food and Drug Administration (FDA). Results The results showed that urinary tract infections (UTIs) were the most reported (59%) infectious diseases. Around 48% of pregnant women received antimicrobial medications at some point during pregnancy. The top two antimicrobial agents based on prescription frequency were B-lactams (44.6%) and azole anti-fungals (30%). The prescribed drugs in the study were found to be from classes B, C and D under the FDA risk classification system. Conclusion The study revealed a high proportion of antimicrobials prescribed during pregnancy that might pose risks to mothers and their fetuses. Future multicenter studies are warranted to evaluate the rational prescription of antimicrobial medications during pregnancy.https://doi.org/10.1186/s40545-020-00292-6Antimicrobial resistanceAntimicrobial drugsInfectionsAntibioticsAntimicrobial stewardship programsDrug utilization pattern |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamed A. Baraka Lina Hussain AlLehaibi Hind Nasser AlSuwaidan Duaa Alsulaiman Md. Ashraful Islam Badriyah Shadid Alotaibi Amany Alboghdadly Ali H. Homoud Fuad H. Al-Ghamdi Mastour S. Al Ghamdi Zaheer-Ud-Din Babar |
spellingShingle |
Mohamed A. Baraka Lina Hussain AlLehaibi Hind Nasser AlSuwaidan Duaa Alsulaiman Md. Ashraful Islam Badriyah Shadid Alotaibi Amany Alboghdadly Ali H. Homoud Fuad H. Al-Ghamdi Mastour S. Al Ghamdi Zaheer-Ud-Din Babar Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional study Journal of Pharmaceutical Policy and Practice Antimicrobial resistance Antimicrobial drugs Infections Antibiotics Antimicrobial stewardship programs Drug utilization pattern |
author_facet |
Mohamed A. Baraka Lina Hussain AlLehaibi Hind Nasser AlSuwaidan Duaa Alsulaiman Md. Ashraful Islam Badriyah Shadid Alotaibi Amany Alboghdadly Ali H. Homoud Fuad H. Al-Ghamdi Mastour S. Al Ghamdi Zaheer-Ud-Din Babar |
author_sort |
Mohamed A. Baraka |
title |
Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional study |
title_short |
Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional study |
title_full |
Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional study |
title_fullStr |
Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional study |
title_full_unstemmed |
Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional study |
title_sort |
patterns of infections and antimicrobial drugs’ prescribing among pregnant women in saudi arabia: a cross sectional study |
publisher |
BMC |
series |
Journal of Pharmaceutical Policy and Practice |
issn |
2052-3211 |
publishDate |
2021-01-01 |
description |
Abstract Background Antimicrobial agents are among the most commonly prescribed drugs in pregnancy due to the increased susceptibility to infections during pregnancy. Antimicrobials can contribute to different maternal complications. Therefore, it is important to study their patterns in prescription and utilization. The data regarding this issue is scarce in Saudi Arabia. Therefore, the aim of this study is to generate data on the antimicrobial agents that are most commonly prescribed during pregnancy as well as their indications and safety. Methods This is a retrospective study focusing on pregnant women with a known antimicrobial use at Johns Hopkins Aramco Healthcare (JHAH). The sample included 344 pregnant women with a total of 688 antimicrobial agents prescribed. Data was collected on the proportion of pregnant women who received antimicrobial agents and on the drug safety during pregnancy using the risk categorization system of the U.S. Food and Drug Administration (FDA). Results The results showed that urinary tract infections (UTIs) were the most reported (59%) infectious diseases. Around 48% of pregnant women received antimicrobial medications at some point during pregnancy. The top two antimicrobial agents based on prescription frequency were B-lactams (44.6%) and azole anti-fungals (30%). The prescribed drugs in the study were found to be from classes B, C and D under the FDA risk classification system. Conclusion The study revealed a high proportion of antimicrobials prescribed during pregnancy that might pose risks to mothers and their fetuses. Future multicenter studies are warranted to evaluate the rational prescription of antimicrobial medications during pregnancy. |
topic |
Antimicrobial resistance Antimicrobial drugs Infections Antibiotics Antimicrobial stewardship programs Drug utilization pattern |
url |
https://doi.org/10.1186/s40545-020-00292-6 |
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