Novel gene function revealed by mouse mutagenesis screens for models of age-related disease
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome se...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12444 |
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DOAJ |
| language |
English |
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Article |
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DOAJ |
| author |
Paul K. Potter Michael R. Bowl Prashanthini Jeyarajan Laura Wisby Andrew Blease Michelle E. Goldsworthy Michelle M. Simon Simon Greenaway Vincent Michel Alun Barnard Carlos Aguilar Thomas Agnew Gareth Banks Andrew Blake Lauren Chessum Joanne Dorning Sara Falcone Laurence Goosey Shelley Harris Andy Haynes Ines Heise Rosie Hillier Tertius Hough Angela Hoslin Marie Hutchison Ruairidh King Saumya Kumar Heena V. Lad Gemma Law Robert E. MacLaren Susan Morse Thomas Nicol Andrew Parker Karen Pickford Siddharth Sethi Becky Starbuck Femke Stelma Michael Cheeseman Sally H. Cross Russell G. Foster Ian J. Jackson Stuart N. Peirson Rajesh V. Thakker Tonia Vincent Cheryl Scudamore Sara Wells Aziz El-Amraoui Christine Petit Abraham Acevedo-Arozena Patrick M. Nolan Roger Cox Anne-Marie Mallon Steve D. M. Brown |
| spellingShingle |
Paul K. Potter Michael R. Bowl Prashanthini Jeyarajan Laura Wisby Andrew Blease Michelle E. Goldsworthy Michelle M. Simon Simon Greenaway Vincent Michel Alun Barnard Carlos Aguilar Thomas Agnew Gareth Banks Andrew Blake Lauren Chessum Joanne Dorning Sara Falcone Laurence Goosey Shelley Harris Andy Haynes Ines Heise Rosie Hillier Tertius Hough Angela Hoslin Marie Hutchison Ruairidh King Saumya Kumar Heena V. Lad Gemma Law Robert E. MacLaren Susan Morse Thomas Nicol Andrew Parker Karen Pickford Siddharth Sethi Becky Starbuck Femke Stelma Michael Cheeseman Sally H. Cross Russell G. Foster Ian J. Jackson Stuart N. Peirson Rajesh V. Thakker Tonia Vincent Cheryl Scudamore Sara Wells Aziz El-Amraoui Christine Petit Abraham Acevedo-Arozena Patrick M. Nolan Roger Cox Anne-Marie Mallon Steve D. M. Brown Novel gene function revealed by mouse mutagenesis screens for models of age-related disease Nature Communications |
| author_facet |
Paul K. Potter Michael R. Bowl Prashanthini Jeyarajan Laura Wisby Andrew Blease Michelle E. Goldsworthy Michelle M. Simon Simon Greenaway Vincent Michel Alun Barnard Carlos Aguilar Thomas Agnew Gareth Banks Andrew Blake Lauren Chessum Joanne Dorning Sara Falcone Laurence Goosey Shelley Harris Andy Haynes Ines Heise Rosie Hillier Tertius Hough Angela Hoslin Marie Hutchison Ruairidh King Saumya Kumar Heena V. Lad Gemma Law Robert E. MacLaren Susan Morse Thomas Nicol Andrew Parker Karen Pickford Siddharth Sethi Becky Starbuck Femke Stelma Michael Cheeseman Sally H. Cross Russell G. Foster Ian J. Jackson Stuart N. Peirson Rajesh V. Thakker Tonia Vincent Cheryl Scudamore Sara Wells Aziz El-Amraoui Christine Petit Abraham Acevedo-Arozena Patrick M. Nolan Roger Cox Anne-Marie Mallon Steve D. M. Brown |
| author_sort |
Paul K. Potter |
| title |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_short |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_full |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_fullStr |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_full_unstemmed |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_sort |
novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-08-01 |
| description |
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome sequencing. |
| url |
https://doi.org/10.1038/ncomms12444 |
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doaj-fa97ab87303c498f824c8286a03253792021-05-11T10:48:58ZengNature Publishing GroupNature Communications2041-17232016-08-017111310.1038/ncomms12444Novel gene function revealed by mouse mutagenesis screens for models of age-related diseasePaul K. Potter0Michael R. Bowl1Prashanthini Jeyarajan2Laura Wisby3Andrew Blease4Michelle E. Goldsworthy5Michelle M. Simon6Simon Greenaway7Vincent Michel8Alun Barnard9Carlos Aguilar10Thomas Agnew11Gareth Banks12Andrew Blake13Lauren Chessum14Joanne Dorning15Sara Falcone16Laurence Goosey17Shelley Harris18Andy Haynes19Ines Heise20Rosie Hillier21Tertius Hough22Angela Hoslin23Marie Hutchison24Ruairidh King25Saumya Kumar26Heena V. Lad27Gemma Law28Robert E. MacLaren29Susan Morse30Thomas Nicol31Andrew Parker32Karen Pickford33Siddharth Sethi34Becky Starbuck35Femke Stelma36Michael Cheeseman37Sally H. Cross38Russell G. Foster39Ian J. Jackson40Stuart N. Peirson41Rajesh V. Thakker42Tonia Vincent43Cheryl Scudamore44Sara Wells45Aziz El-Amraoui46Christine Petit47Abraham Acevedo-Arozena48Patrick M. Nolan49Roger Cox50Anne-Marie Mallon51Steve D. M. Brown52MRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusGénétique et Physiologie de l'Audition, Institut Pasteur, INSERM UMR-S 1120, Sorbonne Universités, UPMC Univ Paris 06, Collège de FranceThe Nuffield Laboratory of Ophthalmology & NIHR Oxford Biomedical Research Centre, University of OxfordMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusThe Nuffield Laboratory of Ophthalmology & NIHR Oxford Biomedical Research Centre, University of OxfordMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of EdinburghMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General HospitalNuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), John Radcliffe Hospital, University of OxfordThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of EdinburghNuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), John Radcliffe Hospital, University of OxfordOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill HospitalNuffield Department of Orthopaedics, Kennedy Institute of Rheumatology, Rheumatology and Musculoskeletal Sciences, University of OxfordMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusGénétique et Physiologie de l'Audition, Institut Pasteur, INSERM UMR-S 1120, Sorbonne Universités, UPMC Univ Paris 06, Collège de FranceGénétique et Physiologie de l'Audition, Institut Pasteur, INSERM UMR-S 1120, Sorbonne Universités, UPMC Univ Paris 06, Collège de FranceMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusRandom mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome sequencing.https://doi.org/10.1038/ncomms12444 |