Accuracy and safety of tablet subdivision
Introduction Tablet subdivision is a common practice among patients and doctors. Tablets can be divided into smaller parts to obtain the desired dose and adjust this dose to the actual needs of the patient. Manipulation of the drug dose is aimed at improvement of the effectiveness of pharmacotherapy...
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Institute of Rural Health
2020-12-01
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doaj-faa651c6ed9e45c3a49c4a7f46870cd52021-01-21T07:04:39ZengInstitute of Rural HealthMedycyna Ogólna i Nauki o Zdrowiu2083-45432084-49052020-12-0126435435910.26444/monz/130681130681Accuracy and safety of tablet subdivisionMichał Meisner0Piotr Kuśnierz1Beata Sarecka-Hujar2Sławomir Wilczyński3Student VI roku Farmacji, Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Farmaceutycznych w Sosnowcu, Katedra i Zakład Podstawowych Nauk Biomedycznych, PolskaStudent VI roku Farmacji, Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Farmaceutycznych w Sosnowcu, Katedra i Zakład Podstawowych Nauk Biomedycznych, PolskaŚląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Farmaceutycznych w Sosnowcu, Katedra i Zakład Podstawowych Nauk Biomedycznych, PolskaŚląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Farmaceutycznych w Sosnowcu, Katedra i Zakład Podstawowych Nauk Biomedycznych, PolskaIntroduction Tablet subdivision is a common practice among patients and doctors. Tablets can be divided into smaller parts to obtain the desired dose and adjust this dose to the actual needs of the patient. Manipulation of the drug dose is aimed at improvement of the effectiveness of pharmacotherapy, reduction of the occurrence of dose-dependent side effects, or minimization of treatment costs. Objective The aim of the study is to discuss the available data concerning the problem of tablets subdivision, the precision of this practice and its safety for the patient. Methods The following databases were searched: PubMed, Google Scholar, Embase using the appropriate key words: „splitting”, „subdivision”, „tablets”, „halves of tablets” (last search in June 2020). State of knowledge Tablet subdivision is performed in the case of drugs requiring a gradual increase in the dose, and then, after a period of appropriate treatment, slowly reducing the dose in order to avoid the increased effects of the withdrawal syndrome resulting from the specific action of these drugs. This applies mainly to antidepressants, neuroleptics, hypnotics and sedatives, as well as anxiolytics used in psychiatric treatment. Parts of tablets are also easier to swallow, which is especially important for patients with swallowing problems (dysphagia). It is estimated that almost half of the population is unable to swallow tablets in full, mainly geriatric patients, children and patients with mental disorders.http://www.monz.pl/Dokladnosc-i-bezpieczenstwo-podzialu-tabletek,130681,0,2.htmltabletsmass uniformitypharmacopeia requirementstabletsubdivisionprecision of subdivision |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michał Meisner Piotr Kuśnierz Beata Sarecka-Hujar Sławomir Wilczyński |
spellingShingle |
Michał Meisner Piotr Kuśnierz Beata Sarecka-Hujar Sławomir Wilczyński Accuracy and safety of tablet subdivision Medycyna Ogólna i Nauki o Zdrowiu tablets mass uniformity pharmacopeia requirements tablet subdivision precision of subdivision |
author_facet |
Michał Meisner Piotr Kuśnierz Beata Sarecka-Hujar Sławomir Wilczyński |
author_sort |
Michał Meisner |
title |
Accuracy and safety of tablet subdivision |
title_short |
Accuracy and safety of tablet subdivision |
title_full |
Accuracy and safety of tablet subdivision |
title_fullStr |
Accuracy and safety of tablet subdivision |
title_full_unstemmed |
Accuracy and safety of tablet subdivision |
title_sort |
accuracy and safety of tablet subdivision |
publisher |
Institute of Rural Health |
series |
Medycyna Ogólna i Nauki o Zdrowiu |
issn |
2083-4543 2084-4905 |
publishDate |
2020-12-01 |
description |
Introduction
Tablet subdivision is a common practice among patients and doctors. Tablets can be divided into smaller parts to obtain the desired dose and adjust this dose to the actual needs of the patient. Manipulation of the drug dose is aimed at improvement of the effectiveness of pharmacotherapy, reduction of the occurrence of dose-dependent side effects, or minimization of treatment costs.
Objective
The aim of the study is to discuss the available data concerning the problem of tablets subdivision, the precision of this practice and its safety for the patient.
Methods
The following databases were searched: PubMed, Google Scholar, Embase using the appropriate key words: „splitting”, „subdivision”, „tablets”, „halves of tablets” (last
search in June 2020).
State of knowledge
Tablet subdivision is performed in the case of drugs requiring a gradual increase in the dose, and then, after a period of appropriate treatment, slowly reducing the dose in order to avoid the increased effects of the withdrawal syndrome resulting from the specific action of these drugs. This applies mainly to antidepressants, neuroleptics, hypnotics and sedatives, as well as anxiolytics used in psychiatric treatment.
Parts of tablets are also easier to swallow, which is especially important for patients with swallowing problems (dysphagia). It is estimated that almost half of the population is unable to swallow tablets in full, mainly geriatric patients, children and patients with mental disorders. |
topic |
tablets mass uniformity pharmacopeia requirements tablet subdivision precision of subdivision |
url |
http://www.monz.pl/Dokladnosc-i-bezpieczenstwo-podzialu-tabletek,130681,0,2.html |
work_keys_str_mv |
AT michałmeisner accuracyandsafetyoftabletsubdivision AT piotrkusnierz accuracyandsafetyoftabletsubdivision AT beatasareckahujar accuracyandsafetyoftabletsubdivision AT sławomirwilczynski accuracyandsafetyoftabletsubdivision |
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