Multi-Step Regulation of the TLR4 Pathway by the miR-125a~99b~let-7e Cluster

Multi-Step Regulation of the TLR4 Pathway by the miR-125a~99b~let-7e Cluster

An appropriate immune response requires a tight balance between pro- and anti-inflammatory mechanisms. IL-10 is induced at late time-points during acute inflammatory conditions triggered by TLR-dependent recognition of infectious agents and is involved in setting this balance, operating as a negativ...

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Bibliographic Details
Main Authors: Graziella Curtale, Tiziana A. Renzi, Massimiliano Mirolo, Lorenzo Drufuca, Manuel Albanese, Mariacristina De Luca, Marzia Rossato, Flavia Bazzoni, Massimo Locati
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
innate immunity
macrophage
TLR
miRNA
IL-10
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02037/full

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