Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ
Background/Aims: Type 2 diabetes is associated with oxidative stress and DNA damage which can cause centrosome amplification. Thus, the study investigated centrosome amplification in type 2 diabetes and the underlying mechanisms. Methods: Centrosome numbers in human peripheral blood mononuclear bloo...
Main Authors: | Pu Wang, Yu Cheng Lu, Jie Wang, Lan Wang, Hanry Yu, Yuan Fei Li, Alice Kong, Juliana Chan, Shaochin Lee |
---|---|
Format: | Article |
Language: | English |
Published: |
Cell Physiol Biochem Press GmbH & Co KG
2018-05-01
|
Series: | Cellular Physiology and Biochemistry |
Subjects: | |
Online Access: | https://www.karger.com/Article/FullText/489812 |
Similar Items
-
Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila
by: Janina Baumbach, et al.
Published: (2012-08-01) -
Conduits of Intratumor Heterogeneity: Centrosome Amplification, Centrosome Clustering and Mitotic Frequency
by: Pannu, Vaishali
Published: (2014) -
Insight into Conformational Change for 14-3-3σ Protein by Molecular Dynamics Simulation
by: Guodong Hu, et al.
Published: (2014-02-01) -
Down-Regulation of 14-3-3σ Reduces Proliferation of Human Lung Cancers But Not Colon Cancer Cells
by: Somrudee Nunun, et al.
Published: (2018-05-01) -
A look into the link between centrosome amplification and breast cancer
by: Yingzi Zhang, et al.
Published: (2020-12-01)