MOLECULAR PROGNOSTIC MARKERS OF URINE BLADDER CANCER

MOLECULAR PROGNOSTIC MARKERS OF URINE BLADDER CANCER

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<p><em>Bladder cancer (BC) remains a current problem in oncourology. Despite that bladder cancer risk factors have been studied and described in the literature, new molecular and genetic mechanisms have been identified that predisposes to the disease development. There are numerous cellu...

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Bibliographic Details
Main Authors: V. N. Pavlov, A. A. Izmailov, L. Z. Akhmadishina, T. V. Victorova, S. M. Izmailova, M. F. Urmantsev, A. V. Alekseev, A. R. Zagitov, L. M. Kutliyarov
Format: Article
Language:Russian
Published: ABV-press 2014-08-01
Series:Onkourologiâ
Subjects:
bladder cancer
genetic markers
prognosis
Online Access:http://oncourology.abvpress.ru/index.php/oncur/article/view/314
Description
Summary:<p><em>Bladder cancer (BC) remains a current problem in oncourology. Despite that bladder cancer risk factors have been studied and described in the literature, new molecular and genetic mechanisms have been identified that predisposes to the disease development. There are numerous cellular processes involve in BC pathogenesis. The less-aggressive, non-invasive slow progressing bladder cancer types are defined by Ras-MAPK system activation. Tumors that are more aggressive and have low cancer-specific survival rate are characterized by changes in retinoblastoma genes and p53. Attempts are made to develop prognostic tests to predict tumor behavior, targeted treatment. perspectively, BC patients will be treated using molecular genetic markers allowing the accurate prediction of the patient’s tumor behavior and fitting the treatment tactics on the individual basis.</em></p>
ISSN:1726-9776
1996-1812

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