Different weight-loss and hypoglycemic effects of exenatide and insulin treatment of patients with newly diagnosed T2DM combined with obesity
Objective: To explore the different weight-loss and hypoglycemic effects of exenatide and insulin treatment of patients with newly diagnosed T2DM combined with obesity. Methods: A total of 98 cases of patients with newly diagnosed T2DM complicated by obesity in this hospital between March 2016 an...
Main Author: | |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2018-04-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201804/15.pdf |
Summary: | Objective: To explore the different weight-loss and hypoglycemic effects of exenatide and
insulin treatment of patients with newly diagnosed T2DM combined with obesity. Methods:
A total of 98 cases of patients with newly diagnosed T2DM complicated by obesity in this
hospital between March 2016 and February 2017 were randomly divided into the control
group (n=49) and the exenatide group (n=49). Control group received oral hypoglycemic
drugs combined with insulin therapy, and exenatide group received exenatide combined with
oral hypoglycemic drug therapy. The differences in BMI levels, blood glucose levels and
inflammatory factor contents were compared between the two groups of patients before and
after treatment. Results: Before treatment, there was no statistically significant difference in
BMI levels, blood glucose index levels in peripheral blood and inflammatory factor contents
in serum between the two groups. After 3 months of treatment, the BMI level in exenatide
group was lower than that in control group; blood glucose indexes FBG and 2h BG levels in
peripheral blood of exenatide group were lower than those of control group; inflammatory
factors IL-6, VCAM-1, MCP-1 and TNF-α contents in serum of exenatide group were lower
than those of control group. Conclusions: Exenatide combined with oral hypoglycemic
drug therapy can more effectively reduce the body weight, optimize the blood glucose level
and relieve the systemic micro-inflammatory state in patients with newly diagnosed T2DM
combined with obesity. |
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ISSN: | 1007-1237 1007-1237 |