The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.

The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.

<h4>Conclusions</h4>These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, sugges...

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Main Authors: Joana Sales-Dias, Gabriela Silva, Márcia Lamy, Andreia Ferreira, Ana Barbas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0217002
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spelling doaj-fabd4a42e3594afe8ba679ae15b999be2021-03-04T10:30:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01145e021700210.1371/journal.pone.0217002The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.Joana Sales-DiasGabriela SilvaMárcia LamyAndreia FerreiraAna Barbas<h4>Conclusions</h4>These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms.https://doi.org/10.1371/journal.pone.0217002
collection DOAJ
language English
format Article
sources DOAJ
author Joana Sales-Dias
Gabriela Silva
Márcia Lamy
Andreia Ferreira
Ana Barbas
spellingShingle Joana Sales-Dias
Gabriela Silva
Márcia Lamy
Andreia Ferreira
Ana Barbas
The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
PLoS ONE
author_facet Joana Sales-Dias
Gabriela Silva
Márcia Lamy
Andreia Ferreira
Ana Barbas
author_sort Joana Sales-Dias
title The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
title_short The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
title_full The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
title_fullStr The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
title_full_unstemmed The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
title_sort notch ligand dll1 exerts carcinogenic features in human breast cancer cells.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2019-01-01
description <h4>Conclusions</h4>These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms.
url https://doi.org/10.1371/journal.pone.0217002
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