Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

Porphyromonas gingivalis is one of the bacterial species most closely associated with periodontitis and can shed large numbers of outer membrane vesicles (OMVs), which are increasingly thought to play a significant role in bacterial virulence and pathogenicity. Macrophages are amongst the first immu...

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Bibliographic Details
Main Authors: Andrew J. Fleetwood, Man K.S. Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M. O'Brien-Simpson, Andrew D. Cook, Andrew J. Murphy, Stuart G. Dashper, Eric C. Reynolds, John A. Hamilton
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
macrophages
metabolism
inflammasome
P. gingivalis
vesicles
pyroptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00351/full

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