An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing
This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using...
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doaj-fad1a05e629a43d18326a614e4b514c82020-11-25T04:10:36ZengMDPI AGApplied Sciences2076-34172020-11-01108303830310.3390/app10228303An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone HealingSyamsiah Syam0Yung-Chieh Cho1Chung-Ming Liu2Mao-Suan Huang3Wen-Chien Lan4Bai-Hung Huang5Takaaki Ueno6Chi-Hsun Tsai7Takashi Saito8May-Show Chen9Keng-Liang Ou10Graduate Institute of Dental Science, College of Dentistry, China Medical University, Taichung 404, TaiwanBiomedical Technology R & D Center, China Medical University Hospital, Taichung 404, TaiwanGraduate Institute of Dental Science, College of Dentistry, China Medical University, Taichung 404, TaiwanDepartment of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, TaiwanDepartment of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung 203, TaiwanBiomedical Technology R & D Center, China Medical University Hospital, Taichung 404, TaiwanDepartment of Dentistry and Oral Surgery, Osaka Medical College, Osaka 569-8686, JapanDivision of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, JapanDivision of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, JapanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanBiomedical Technology R & D Center, China Medical University Hospital, Taichung 404, TaiwanThis study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat’s right hind leg bone and observed histologically after three days and seven weeks. The material was also implanted in patients with bone defects in the posterior maxillary, then observed immediately and six months post-treatment by panoramic and computed tomography image. The FE-SEM confirm this material is a uniform-shaped short column crystal, while the EDS measurement reveals calcium as the most component in this material. Thermal observation shows temperature change during the setting time is less than 2 °C, and the maximum temperature reached is 31 °C. In the histological analysis, α-CSH bioceramic shows new trabecular bone formation and absorbed material at seven weeks post-treatment. Moreover, panoramic and computed tomography image shows intact bone six months post-treatment. Therefore, this study suggests that the innovative α-CSH bioceramic can be useful in bone defect treatment.https://www.mdpi.com/2076-3417/10/22/8303α-calcium sulfate hemihydratebioceramicbone graftbone defect treatmentbone healingbone regeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Syamsiah Syam Yung-Chieh Cho Chung-Ming Liu Mao-Suan Huang Wen-Chien Lan Bai-Hung Huang Takaaki Ueno Chi-Hsun Tsai Takashi Saito May-Show Chen Keng-Liang Ou |
spellingShingle |
Syamsiah Syam Yung-Chieh Cho Chung-Ming Liu Mao-Suan Huang Wen-Chien Lan Bai-Hung Huang Takaaki Ueno Chi-Hsun Tsai Takashi Saito May-Show Chen Keng-Liang Ou An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing Applied Sciences α-calcium sulfate hemihydrate bioceramic bone graft bone defect treatment bone healing bone regeneration |
author_facet |
Syamsiah Syam Yung-Chieh Cho Chung-Ming Liu Mao-Suan Huang Wen-Chien Lan Bai-Hung Huang Takaaki Ueno Chi-Hsun Tsai Takashi Saito May-Show Chen Keng-Liang Ou |
author_sort |
Syamsiah Syam |
title |
An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing |
title_short |
An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing |
title_full |
An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing |
title_fullStr |
An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing |
title_full_unstemmed |
An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing |
title_sort |
innovative bioceramic bone graft substitute for bone defect treatment: in vivo evaluation of bone healing |
publisher |
MDPI AG |
series |
Applied Sciences |
issn |
2076-3417 |
publishDate |
2020-11-01 |
description |
This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat’s right hind leg bone and observed histologically after three days and seven weeks. The material was also implanted in patients with bone defects in the posterior maxillary, then observed immediately and six months post-treatment by panoramic and computed tomography image. The FE-SEM confirm this material is a uniform-shaped short column crystal, while the EDS measurement reveals calcium as the most component in this material. Thermal observation shows temperature change during the setting time is less than 2 °C, and the maximum temperature reached is 31 °C. In the histological analysis, α-CSH bioceramic shows new trabecular bone formation and absorbed material at seven weeks post-treatment. Moreover, panoramic and computed tomography image shows intact bone six months post-treatment. Therefore, this study suggests that the innovative α-CSH bioceramic can be useful in bone defect treatment. |
topic |
α-calcium sulfate hemihydrate bioceramic bone graft bone defect treatment bone healing bone regeneration |
url |
https://www.mdpi.com/2076-3417/10/22/8303 |
work_keys_str_mv |
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