Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up
Cristina Ariadna Nicula,1,2 Anca Maria Rednik,3 Ariadna Patricia Nicula,4 Adriana Elena Bulboaca,5 Dorin Nicula,2 Karin Ursula Horvath6 1Department of Ophthalmology, Medicine and Pharmacy University “Iuliu Hațieganu”, Cluj-Napoca, Romania; 2Oculens Clinic, Cluj-Napoca, Romania; 3Eye County Hospital,...
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doaj-fad6c290ebac447b91e870c6b3a1102f2021-09-07T20:56:36ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2021-09-01Volume 1797598868625Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-UpNicula CARednik AMNicula APBulboaca AENicula DHorvath KUCristina Ariadna Nicula,1,2 Anca Maria Rednik,3 Ariadna Patricia Nicula,4 Adriana Elena Bulboaca,5 Dorin Nicula,2 Karin Ursula Horvath6 1Department of Ophthalmology, Medicine and Pharmacy University “Iuliu Hațieganu”, Cluj-Napoca, Romania; 2Oculens Clinic, Cluj-Napoca, Romania; 3Eye County Hospital, Department of Ophthalmology, Cluj-Napoca, Romania; 4Eye County Hospital, Department of Ophthalmology, Arad, Romania; 5Department of Pathophysiology, Medicine and Pharmacy University “Iuliu Hațieganu”, Cluj Napoca, Romania; 6Department of Ophthalmology, Medicine and Pharmacy Science and Technology University “George Emil Palade”, Târgu Mureș, RomaniaCorrespondence: Cristina Ariadna NiculaDepartment of Ophthalmology, Medicine and Pharmacy University “Iuliu Hațieganu”, Cluj-Napoca, RomaniaTel +011 40-722849575Email niculacristina65@yahoo.comPurpose: The purpose of the present study was to assess the long-term efficiency and safety of the “epi-off” accelerated CXL (9 mW/cm2 for 10 minutes) in comparison to the standard “epi-off” CXL (3 mW/cm2 for 30 minutes) in terms of topographical and keratometric parameters, refractive data and visual outcomes at 7 years of follow-up, in progressive keratoconus.Material and Method: A retrospective and comparative study was performed. A total of 183 eyes from 183 patients with documented progressive keratoconus were included in the study. The patients were divided in two groups: 93 eyes from 93 patients underwent “epi-off” standard cross-linking technique (3 mW/cm2 for 30 minutes) (S-CXL group) and 90 eyes from 90 patients underwent accelerated “epi-off” corneal CXL technique (9 mW/cm2 for 10 minutes) (A-CXL group).Results: Improvements in uncorrected distance visual acuity (UDVA) were statistically significant compared to baseline values in both groups at each time-point visit (p=0.0421 at 1 year, p=0.0411 at 7 years for A-CXL and p=0.0375 at 1 year, p=0.0389 at 7 years for S-CXL). At 7 years there was a statistically significant increase in CDVA (p=0.039 in the A-CXL group and p=0.0343 in the S-CXL group at 7 years). Statistically significant reduction was noticed in Ksteep (p=0.0411 in A-CXL group and p=0.0224 in S-CXL group), Kflat (p=0.0198 in A-CXL group and p=0.008 in S-CXL group), K mean (p=0.0106 in A-CXL group and p=0.0193 in S-CXL group) and Kmax (p=0.0413 in A-CXL group and p=0.054 in S-CXL group) at 7 years, compared to baseline values, in both groups, but without any statistically difference between the two procedures, at all time-point visits (p> 0.05).Conclusion: The long-term outcomes of “epi-off” accelerated corneal collagen crosslinking-UVA (9 mW/cm2 for 10 minutes) are similar to standard “epi-off” corneal collagen crosslinking procedure in the treatment of progressive keratoconus.Keywords: progression, keratoconus, accelerated cross-linking, standard cross-linkinghttps://www.dovepress.com/comparative-results-between-epi-off-accelerated-and-epi-off-standard-c-peer-reviewed-fulltext-article-TCRMprogressionkeratoconusaccelerated cross-linkingstandard cross-linking |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicula CA Rednik AM Nicula AP Bulboaca AE Nicula D Horvath KU |
spellingShingle |
Nicula CA Rednik AM Nicula AP Bulboaca AE Nicula D Horvath KU Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up Therapeutics and Clinical Risk Management progression keratoconus accelerated cross-linking standard cross-linking |
author_facet |
Nicula CA Rednik AM Nicula AP Bulboaca AE Nicula D Horvath KU |
author_sort |
Nicula CA |
title |
Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up |
title_short |
Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up |
title_full |
Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up |
title_fullStr |
Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up |
title_full_unstemmed |
Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up |
title_sort |
comparative results between “epi-off” accelerated and “epi-off” standard corneal collagen crosslinking-uva in progressive keratoconus – 7 years of follow-up |
publisher |
Dove Medical Press |
series |
Therapeutics and Clinical Risk Management |
issn |
1178-203X |
publishDate |
2021-09-01 |
description |
Cristina Ariadna Nicula,1,2 Anca Maria Rednik,3 Ariadna Patricia Nicula,4 Adriana Elena Bulboaca,5 Dorin Nicula,2 Karin Ursula Horvath6 1Department of Ophthalmology, Medicine and Pharmacy University “Iuliu Hațieganu”, Cluj-Napoca, Romania; 2Oculens Clinic, Cluj-Napoca, Romania; 3Eye County Hospital, Department of Ophthalmology, Cluj-Napoca, Romania; 4Eye County Hospital, Department of Ophthalmology, Arad, Romania; 5Department of Pathophysiology, Medicine and Pharmacy University “Iuliu Hațieganu”, Cluj Napoca, Romania; 6Department of Ophthalmology, Medicine and Pharmacy Science and Technology University “George Emil Palade”, Târgu Mureș, RomaniaCorrespondence: Cristina Ariadna NiculaDepartment of Ophthalmology, Medicine and Pharmacy University “Iuliu Hațieganu”, Cluj-Napoca, RomaniaTel +011 40-722849575Email niculacristina65@yahoo.comPurpose: The purpose of the present study was to assess the long-term efficiency and safety of the “epi-off” accelerated CXL (9 mW/cm2 for 10 minutes) in comparison to the standard “epi-off” CXL (3 mW/cm2 for 30 minutes) in terms of topographical and keratometric parameters, refractive data and visual outcomes at 7 years of follow-up, in progressive keratoconus.Material and Method: A retrospective and comparative study was performed. A total of 183 eyes from 183 patients with documented progressive keratoconus were included in the study. The patients were divided in two groups: 93 eyes from 93 patients underwent “epi-off” standard cross-linking technique (3 mW/cm2 for 30 minutes) (S-CXL group) and 90 eyes from 90 patients underwent accelerated “epi-off” corneal CXL technique (9 mW/cm2 for 10 minutes) (A-CXL group).Results: Improvements in uncorrected distance visual acuity (UDVA) were statistically significant compared to baseline values in both groups at each time-point visit (p=0.0421 at 1 year, p=0.0411 at 7 years for A-CXL and p=0.0375 at 1 year, p=0.0389 at 7 years for S-CXL). At 7 years there was a statistically significant increase in CDVA (p=0.039 in the A-CXL group and p=0.0343 in the S-CXL group at 7 years). Statistically significant reduction was noticed in Ksteep (p=0.0411 in A-CXL group and p=0.0224 in S-CXL group), Kflat (p=0.0198 in A-CXL group and p=0.008 in S-CXL group), K mean (p=0.0106 in A-CXL group and p=0.0193 in S-CXL group) and Kmax (p=0.0413 in A-CXL group and p=0.054 in S-CXL group) at 7 years, compared to baseline values, in both groups, but without any statistically difference between the two procedures, at all time-point visits (p> 0.05).Conclusion: The long-term outcomes of “epi-off” accelerated corneal collagen crosslinking-UVA (9 mW/cm2 for 10 minutes) are similar to standard “epi-off” corneal collagen crosslinking procedure in the treatment of progressive keratoconus.Keywords: progression, keratoconus, accelerated cross-linking, standard cross-linking |
topic |
progression keratoconus accelerated cross-linking standard cross-linking |
url |
https://www.dovepress.com/comparative-results-between-epi-off-accelerated-and-epi-off-standard-c-peer-reviewed-fulltext-article-TCRM |
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