Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications
Abstract Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are crucial regulators in multiple cellular biological processes, and thus engage in th...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-01-01
|
Series: | Arthritis Research & Therapy |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13075-021-02420-2 |
id |
doaj-fae2b83084f4447bbb6a8100058644b9 |
---|---|
record_format |
Article |
spelling |
doaj-fae2b83084f4447bbb6a8100058644b92021-01-17T12:58:01ZengBMCArthritis Research & Therapy1478-63622021-01-0123111510.1186/s13075-021-02420-2Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implicationsWenchao Zhang0Lin Qi1Ruiqi Chen2Jieyu He3Zhongyue Liu4Wanchun Wang5Chao Tu6Zhihong Li7Department of Orthopedics, The Second Xiangya Hospital, Central South UniversityDepartment of Orthopedics, The Second Xiangya Hospital, Central South UniversityDepartment of Orthopedics, The Second Xiangya Hospital, Central South UniversityDepartment of Geriatrics, The Second Xiangya Hospital, Central South UniversityDepartment of Orthopedics, The Second Xiangya Hospital, Central South UniversityDepartment of Orthopedics, The Second Xiangya Hospital, Central South UniversityDepartment of Orthopedics, The Second Xiangya Hospital, Central South UniversityDepartment of Orthopedics, The Second Xiangya Hospital, Central South UniversityAbstract Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are crucial regulators in multiple cellular biological processes, and thus engage in the development and progression of many diseases including osteoarthritis (OA). OA is a prevalent disease that mainly affects those aging, obese and post-traumatic population, posing as a major source of socioeconomic burden. Recently, numerous circRNAs have been found aberrantly expressed in OA tissues compared with counterparts. More importantly, circRNAs have been demonstrated to interplay with components in OA microenvironments, such as chondrocytes, synoviocytes and macrophages, by regulation of their proliferation, apoptosis, autophagy, inflammation, or extracellular matrix reorganization. Herein, in this review, we extensively summarize the roles of circRNAs in OA microenvironment, progression, and putative treatment, as well as envision the future directions for circRNAs research in OA, with the aim to provide a novel insight into this field.https://doi.org/10.1186/s13075-021-02420-2Circular RNAsOsteoarthritisMicroenvironmentChondrocytesExtracellular matrix |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenchao Zhang Lin Qi Ruiqi Chen Jieyu He Zhongyue Liu Wanchun Wang Chao Tu Zhihong Li |
spellingShingle |
Wenchao Zhang Lin Qi Ruiqi Chen Jieyu He Zhongyue Liu Wanchun Wang Chao Tu Zhihong Li Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications Arthritis Research & Therapy Circular RNAs Osteoarthritis Microenvironment Chondrocytes Extracellular matrix |
author_facet |
Wenchao Zhang Lin Qi Ruiqi Chen Jieyu He Zhongyue Liu Wanchun Wang Chao Tu Zhihong Li |
author_sort |
Wenchao Zhang |
title |
Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications |
title_short |
Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications |
title_full |
Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications |
title_fullStr |
Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications |
title_full_unstemmed |
Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications |
title_sort |
circular rnas in osteoarthritis: indispensable regulators and novel strategies in clinical implications |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2021-01-01 |
description |
Abstract Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are crucial regulators in multiple cellular biological processes, and thus engage in the development and progression of many diseases including osteoarthritis (OA). OA is a prevalent disease that mainly affects those aging, obese and post-traumatic population, posing as a major source of socioeconomic burden. Recently, numerous circRNAs have been found aberrantly expressed in OA tissues compared with counterparts. More importantly, circRNAs have been demonstrated to interplay with components in OA microenvironments, such as chondrocytes, synoviocytes and macrophages, by regulation of their proliferation, apoptosis, autophagy, inflammation, or extracellular matrix reorganization. Herein, in this review, we extensively summarize the roles of circRNAs in OA microenvironment, progression, and putative treatment, as well as envision the future directions for circRNAs research in OA, with the aim to provide a novel insight into this field. |
topic |
Circular RNAs Osteoarthritis Microenvironment Chondrocytes Extracellular matrix |
url |
https://doi.org/10.1186/s13075-021-02420-2 |
work_keys_str_mv |
AT wenchaozhang circularrnasinosteoarthritisindispensableregulatorsandnovelstrategiesinclinicalimplications AT linqi circularrnasinosteoarthritisindispensableregulatorsandnovelstrategiesinclinicalimplications AT ruiqichen circularrnasinosteoarthritisindispensableregulatorsandnovelstrategiesinclinicalimplications AT jieyuhe circularrnasinosteoarthritisindispensableregulatorsandnovelstrategiesinclinicalimplications AT zhongyueliu circularrnasinosteoarthritisindispensableregulatorsandnovelstrategiesinclinicalimplications AT wanchunwang circularrnasinosteoarthritisindispensableregulatorsandnovelstrategiesinclinicalimplications AT chaotu circularrnasinosteoarthritisindispensableregulatorsandnovelstrategiesinclinicalimplications AT zhihongli circularrnasinosteoarthritisindispensableregulatorsandnovelstrategiesinclinicalimplications |
_version_ |
1724334224383672320 |