Keratinocyte Binding Assay Identifies Anti-Desmosomal Pemphigus Antibodies Where Other Tests Are Negative

Keratinocyte Binding Assay Identifies Anti-Desmosomal Pemphigus Antibodies Where Other Tests Are Negative

The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA. Although being highly sensitive and specific tools, discrepanc...

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Bibliographic Details
Main Authors: Federica Giurdanella, Albertine M. Nijenhuis, Gilles F. H. Diercks, Marcel F. Jonkman, Hendri H. Pas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
pemphigus
diagnosis
autoantibodies
desmosomes
desmogleins
keratinocyte
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00839/full

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