Studying Network Mechanisms using Intracranial Stimulation in Epileptic Patients
Patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes allow to obtain data of exceptional value for studying brain dynamics in correlation with pathophysiological and cognitive processes. Direct electrical stimulation (DES) of cortical regions and axona...
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2010-10-01
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doaj-faedac79bc374a18b26fb4c1267b35e92020-11-25T00:51:46ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372010-10-01410.3389/fnsys.2010.001482063Studying Network Mechanisms using Intracranial Stimulation in Epileptic PatientsOlivier David0Olivier David1Olivier David2Julien Bastin3Julien Bastin4Stéphan Chabardès5Stéphan Chabardès6Stéphan Chabardès7Lorella Minotti8Lorella Minotti9Lorella Minotti10Philippe Kahane11Philippe Kahane12Philippe Kahane13Philippe Kahane14Inserm U836 Grenoble Institut des NeurosciencesUniversité Joseph FourierGrenoble University Hospital (CHU)Inserm U836 Grenoble Institut des NeurosciencesUniversité Joseph FourierInserm U836 Grenoble Institut des NeurosciencesUniversité Joseph FourierGrenoble University Hospital (CHU)Inserm U836 Grenoble Institut des NeurosciencesUniversité Joseph FourierGrenoble University Hospital (CHU)Inserm U836 Grenoble Institut des NeurosciencesUniversité Joseph FourierGrenoble University Hospital (CHU)Neurological HospitalPatients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes allow to obtain data of exceptional value for studying brain dynamics in correlation with pathophysiological and cognitive processes. Direct electrical stimulation (DES) of cortical regions and axonal tracts in those patients elicits a number of very specific perceptual or behavioural responses, but also abnormal responses due to specific configurations of epileptic networks. Here, we review how anatomo-functional brain connectivity and epilepsy network mechanisms can be assessed from DES responses measured in patients. After a brief summary of mechanisms of action of brain electrical stimulation, we recall the conceptual framework for interpreting DES results in the context of brain connectivity and review how DES can be used for the characterisation of functional networks, the identification of the seizure onset zone, the study of brain plasticity mechanisms, and the anticipation of epileptic seizures. This pool of exceptional data may be underexploited by fundamental research on brain connectivity and leaves much to be learned.http://journal.frontiersin.org/Journal/10.3389/fnsys.2010.00148/fullCognitionElectroencephalographyEpilepsyconnectivityplasticitynetworks |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Olivier David Olivier David Olivier David Julien Bastin Julien Bastin Stéphan Chabardès Stéphan Chabardès Stéphan Chabardès Lorella Minotti Lorella Minotti Lorella Minotti Philippe Kahane Philippe Kahane Philippe Kahane Philippe Kahane |
spellingShingle |
Olivier David Olivier David Olivier David Julien Bastin Julien Bastin Stéphan Chabardès Stéphan Chabardès Stéphan Chabardès Lorella Minotti Lorella Minotti Lorella Minotti Philippe Kahane Philippe Kahane Philippe Kahane Philippe Kahane Studying Network Mechanisms using Intracranial Stimulation in Epileptic Patients Frontiers in Systems Neuroscience Cognition Electroencephalography Epilepsy connectivity plasticity networks |
author_facet |
Olivier David Olivier David Olivier David Julien Bastin Julien Bastin Stéphan Chabardès Stéphan Chabardès Stéphan Chabardès Lorella Minotti Lorella Minotti Lorella Minotti Philippe Kahane Philippe Kahane Philippe Kahane Philippe Kahane |
author_sort |
Olivier David |
title |
Studying Network Mechanisms using Intracranial Stimulation in Epileptic Patients |
title_short |
Studying Network Mechanisms using Intracranial Stimulation in Epileptic Patients |
title_full |
Studying Network Mechanisms using Intracranial Stimulation in Epileptic Patients |
title_fullStr |
Studying Network Mechanisms using Intracranial Stimulation in Epileptic Patients |
title_full_unstemmed |
Studying Network Mechanisms using Intracranial Stimulation in Epileptic Patients |
title_sort |
studying network mechanisms using intracranial stimulation in epileptic patients |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Systems Neuroscience |
issn |
1662-5137 |
publishDate |
2010-10-01 |
description |
Patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes allow to obtain data of exceptional value for studying brain dynamics in correlation with pathophysiological and cognitive processes. Direct electrical stimulation (DES) of cortical regions and axonal tracts in those patients elicits a number of very specific perceptual or behavioural responses, but also abnormal responses due to specific configurations of epileptic networks. Here, we review how anatomo-functional brain connectivity and epilepsy network mechanisms can be assessed from DES responses measured in patients. After a brief summary of mechanisms of action of brain electrical stimulation, we recall the conceptual framework for interpreting DES results in the context of brain connectivity and review how DES can be used for the characterisation of functional networks, the identification of the seizure onset zone, the study of brain plasticity mechanisms, and the anticipation of epileptic seizures. This pool of exceptional data may be underexploited by fundamental research on brain connectivity and leaves much to be learned. |
topic |
Cognition Electroencephalography Epilepsy connectivity plasticity networks |
url |
http://journal.frontiersin.org/Journal/10.3389/fnsys.2010.00148/full |
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