Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus
Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of...
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MDPI AG
2015-03-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/13/3/1290 |
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doaj-faff75627d014c76bcf39c363f78dc142020-11-25T02:25:08ZengMDPI AGMarine Drugs1660-33972015-03-011331290130310.3390/md13031290md13031290Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreusMinjung You0Lijuan Liao1Soo Hyun Hong2Wanki Park3Dah In Kwon4Jeeyeon Lee5Minsoo Noh6Dong-Chan Oh7Ki-Bong Oh8Jongheon Shin9Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaDepartment of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, KoreaCollege of Pharmacy, Seoul National University, Seoul 151-742, KoreaCollege of Pharmacy, Seoul National University, Seoul 151-742, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaDepartment of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaTerrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells. In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition.http://www.mdpi.com/1660-3397/13/3/1290lumazinepeptideAspergillus terreusinsulin sensitivity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Minjung You Lijuan Liao Soo Hyun Hong Wanki Park Dah In Kwon Jeeyeon Lee Minsoo Noh Dong-Chan Oh Ki-Bong Oh Jongheon Shin |
| spellingShingle |
Minjung You Lijuan Liao Soo Hyun Hong Wanki Park Dah In Kwon Jeeyeon Lee Minsoo Noh Dong-Chan Oh Ki-Bong Oh Jongheon Shin Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus Marine Drugs lumazine peptide Aspergillus terreus insulin sensitivity |
| author_facet |
Minjung You Lijuan Liao Soo Hyun Hong Wanki Park Dah In Kwon Jeeyeon Lee Minsoo Noh Dong-Chan Oh Ki-Bong Oh Jongheon Shin |
| author_sort |
Minjung You |
| title |
Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus |
| title_short |
Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus |
| title_full |
Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus |
| title_fullStr |
Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus |
| title_full_unstemmed |
Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus |
| title_sort |
lumazine peptides from the marine-derived fungus aspergillus terreus |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2015-03-01 |
| description |
Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells. In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition. |
| topic |
lumazine peptide Aspergillus terreus insulin sensitivity |
| url |
http://www.mdpi.com/1660-3397/13/3/1290 |
| work_keys_str_mv |
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