ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.
Bibliographic Details
| Main Authors: |
Mingdong Liu,
Taoling Zeng,
Xin Zhang,
Chunyan Liu,
Zhihui Wu,
Luming Yao,
Changchuan Xie,
Hui Xia,
Qi Lin,
Liping Xie,
Dawang Zhou,
Xianming Deng,
Hong-Lin Chan,
Tong-Jin Zhao,
Hong-Rui Wang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-06556-9
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