ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.

Bibliographic Details
Main Authors:	Mingdong Liu, Taoling Zeng, Xin Zhang, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao, Hong-Rui Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06556-9

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spelling	doaj-fb0cf4ef163142abb62caefcf0ec80c72021-05-11T09:45:41ZengNature Publishing GroupNature Communications2041-17232018-10-019111410.1038/s41467-018-06556-9ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damageMingdong Liu0Taoling Zeng1Xin Zhang2Chunyan Liu3Zhihui Wu4Luming Yao5Changchuan Xie6Hui Xia7Qi Lin8Liping Xie9Dawang Zhou10Xianming Deng11Hong-Lin Chan12Tong-Jin Zhao13Hong-Rui Wang14State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityInstitute of Bioinformatics and Structural Biology, Department of Medical Sciences, National Tsing Hua UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityDNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.https://doi.org/10.1038/s41467-018-06556-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mingdong Liu Taoling Zeng Xin Zhang Chunyan Liu Zhihui Wu Luming Yao Changchuan Xie Hui Xia Qi Lin Liping Xie Dawang Zhou Xianming Deng Hong-Lin Chan Tong-Jin Zhao Hong-Rui Wang
spellingShingle	Mingdong Liu Taoling Zeng Xin Zhang Chunyan Liu Zhihui Wu Luming Yao Changchuan Xie Hui Xia Qi Lin Liping Xie Dawang Zhou Xianming Deng Hong-Lin Chan Tong-Jin Zhao Hong-Rui Wang ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage Nature Communications
author_facet	Mingdong Liu Taoling Zeng Xin Zhang Chunyan Liu Zhihui Wu Luming Yao Changchuan Xie Hui Xia Qi Lin Liping Xie Dawang Zhou Xianming Deng Hong-Lin Chan Tong-Jin Zhao Hong-Rui Wang
author_sort	Mingdong Liu
title	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_short	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_full	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_fullStr	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_full_unstemmed	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_sort	atr/chk1 signaling induces autophagy through sumoylated rhob-mediated lysosomal translocation of tsc2 after dna damage
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-10-01
description	DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.
url	https://doi.org/10.1038/s41467-018-06556-9
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ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

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