Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia
Diagnosis of vascular dementia is hampered by the lack of biochemical markers for this disease. Here, the authors show that vascular dementia is associated with increased lipocalin-2 in cerebrospinal fluid, compared to controls and patients with other forms of dementia.
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14373-2 |
| id |
doaj-fb0e9a75338a4a03b999da9efd91d3b8 |
|---|---|
| record_format |
Article |
| spelling |
doaj-fb0e9a75338a4a03b999da9efd91d3b82021-05-11T07:59:01ZengNature Publishing GroupNature Communications2041-17232020-01-0111111110.1038/s41467-020-14373-2Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementiaFranc Llorens0Peter Hermann1Anna Villar-Piqué2Daniela Diaz-Lucena3Katarina Nägga4Oskar Hansson5Isabel Santana6Matthias Schmitz7Christian Schmidt8Daniela Varges9Stefan Goebel10Julien Dumurgier11Henrik Zetterberg12Kaj Blennow13Claire Paquet14Inês Baldeiras15Isidro Ferrer16Inga Zerr17Department of Neurology, University Medical Center GöttingenDepartment of Neurology, University Medical Center GöttingenDepartment of Neurology, University Medical Center GöttingenNetwork center for biomedical research of neurodegenerative diseases (CIBERNED), Institute Carlos III, Ministry of HealthDepartment of Acute Internal Medicine and Geriatrics, Linköping UniversityMemory Clinic, Skåne University HospitalNeurology Department, CHUC—Centro Hospitalar e Universitário de Coimbra, CNC- Center for Neuroscience and Cell Biology; Faculty of Medicine, University of CoimbraDepartment of Neurology, University Medical Center GöttingenDepartment of Neurology, University Medical Center GöttingenDepartment of Neurology, University Medical Center GöttingenDepartment of Neurology, University Medical Center GöttingenCenter of Cognitive Neurology and Inserm U942 Lariboisière Hospital AP-HP University Paris DiderotDepartment of Neurodegenerative Disease, Institute of Neurology, University College LondonClinical Neurochemistry Laboratory, Sahlgrenska University HospitalCenter of Cognitive Neurology and Inserm U942 Lariboisière Hospital AP-HP University Paris DiderotNeurology Department, CHUC—Centro Hospitalar e Universitário de Coimbra, CNC- Center for Neuroscience and Cell Biology; Faculty of Medicine, University of CoimbraNetwork center for biomedical research of neurodegenerative diseases (CIBERNED), Institute Carlos III, Ministry of HealthDepartment of Neurology, University Medical Center GöttingenDiagnosis of vascular dementia is hampered by the lack of biochemical markers for this disease. Here, the authors show that vascular dementia is associated with increased lipocalin-2 in cerebrospinal fluid, compared to controls and patients with other forms of dementia.https://doi.org/10.1038/s41467-020-14373-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Franc Llorens Peter Hermann Anna Villar-Piqué Daniela Diaz-Lucena Katarina Nägga Oskar Hansson Isabel Santana Matthias Schmitz Christian Schmidt Daniela Varges Stefan Goebel Julien Dumurgier Henrik Zetterberg Kaj Blennow Claire Paquet Inês Baldeiras Isidro Ferrer Inga Zerr |
| spellingShingle |
Franc Llorens Peter Hermann Anna Villar-Piqué Daniela Diaz-Lucena Katarina Nägga Oskar Hansson Isabel Santana Matthias Schmitz Christian Schmidt Daniela Varges Stefan Goebel Julien Dumurgier Henrik Zetterberg Kaj Blennow Claire Paquet Inês Baldeiras Isidro Ferrer Inga Zerr Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia Nature Communications |
| author_facet |
Franc Llorens Peter Hermann Anna Villar-Piqué Daniela Diaz-Lucena Katarina Nägga Oskar Hansson Isabel Santana Matthias Schmitz Christian Schmidt Daniela Varges Stefan Goebel Julien Dumurgier Henrik Zetterberg Kaj Blennow Claire Paquet Inês Baldeiras Isidro Ferrer Inga Zerr |
| author_sort |
Franc Llorens |
| title |
Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia |
| title_short |
Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia |
| title_full |
Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia |
| title_fullStr |
Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia |
| title_full_unstemmed |
Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia |
| title_sort |
cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Diagnosis of vascular dementia is hampered by the lack of biochemical markers for this disease. Here, the authors show that vascular dementia is associated with increased lipocalin-2 in cerebrospinal fluid, compared to controls and patients with other forms of dementia. |
| url |
https://doi.org/10.1038/s41467-020-14373-2 |
| work_keys_str_mv |
AT francllorens cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT peterhermann cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT annavillarpique cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT danieladiazlucena cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT katarinanagga cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT oskarhansson cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT isabelsantana cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT matthiasschmitz cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT christianschmidt cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT danielavarges cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT stefangoebel cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT juliendumurgier cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT henrikzetterberg cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT kajblennow cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT clairepaquet cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT inesbaldeiras cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT isidroferrer cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia AT ingazerr cerebrospinalfluidlipocalin2asanovelbiomarkerforthedifferentialdiagnosisofvasculardementia |
| _version_ |
1721451348672643072 |