Mitophagy: A New Player in Stem Cell Biology
The fundamental importance of functional mitochondria in the survival of most eukaryotic cells, through regulation of bioenergetics, cell death, calcium dynamics and reactive oxygen species (ROS) generation, is undisputed. However, with new avenues of research in stem cell biology these organelles h...
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doaj-fb11f685f0ab468dae14d25df778a47b2020-12-20T00:02:40ZengMDPI AGBiology2079-77372020-12-01948148110.3390/biology9120481Mitophagy: A New Player in Stem Cell BiologyGeorge Cairns0Madhavee Thumiah-Mootoo1Yan Burelle2Mireille Khacho3Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 7K4, CanadaDepartment of Cellular & Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaInterdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 7K4, CanadaCenter for Neuromuscular Disease, Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology (OISB), Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaThe fundamental importance of functional mitochondria in the survival of most eukaryotic cells, through regulation of bioenergetics, cell death, calcium dynamics and reactive oxygen species (ROS) generation, is undisputed. However, with new avenues of research in stem cell biology these organelles have now emerged as signaling entities, actively involved in many aspects of stem cell functions, including self-renewal, commitment and differentiation. With this recent knowledge, it becomes evident that regulatory pathways that would ensure the maintenance of mitochondria with state-specific characteristics and the selective removal of organelles with sub-optimal functions must play a pivotal role in stem cells. As such, mitophagy, as an essential mitochondrial quality control mechanism, is beginning to gain appreciation within the stem cell field. Here we review and discuss recent advances in our knowledge pertaining to the roles of mitophagy in stem cell functions and the potential contributions of this specific quality control process on to the progression of aging and diseases.https://www.mdpi.com/2079-7737/9/12/481mitophagystem cellsself-renewalmitochondriametabolismmitochondrial quality control |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
George Cairns Madhavee Thumiah-Mootoo Yan Burelle Mireille Khacho |
spellingShingle |
George Cairns Madhavee Thumiah-Mootoo Yan Burelle Mireille Khacho Mitophagy: A New Player in Stem Cell Biology Biology mitophagy stem cells self-renewal mitochondria metabolism mitochondrial quality control |
author_facet |
George Cairns Madhavee Thumiah-Mootoo Yan Burelle Mireille Khacho |
author_sort |
George Cairns |
title |
Mitophagy: A New Player in Stem Cell Biology |
title_short |
Mitophagy: A New Player in Stem Cell Biology |
title_full |
Mitophagy: A New Player in Stem Cell Biology |
title_fullStr |
Mitophagy: A New Player in Stem Cell Biology |
title_full_unstemmed |
Mitophagy: A New Player in Stem Cell Biology |
title_sort |
mitophagy: a new player in stem cell biology |
publisher |
MDPI AG |
series |
Biology |
issn |
2079-7737 |
publishDate |
2020-12-01 |
description |
The fundamental importance of functional mitochondria in the survival of most eukaryotic cells, through regulation of bioenergetics, cell death, calcium dynamics and reactive oxygen species (ROS) generation, is undisputed. However, with new avenues of research in stem cell biology these organelles have now emerged as signaling entities, actively involved in many aspects of stem cell functions, including self-renewal, commitment and differentiation. With this recent knowledge, it becomes evident that regulatory pathways that would ensure the maintenance of mitochondria with state-specific characteristics and the selective removal of organelles with sub-optimal functions must play a pivotal role in stem cells. As such, mitophagy, as an essential mitochondrial quality control mechanism, is beginning to gain appreciation within the stem cell field. Here we review and discuss recent advances in our knowledge pertaining to the roles of mitophagy in stem cell functions and the potential contributions of this specific quality control process on to the progression of aging and diseases. |
topic |
mitophagy stem cells self-renewal mitochondria metabolism mitochondrial quality control |
url |
https://www.mdpi.com/2079-7737/9/12/481 |
work_keys_str_mv |
AT georgecairns mitophagyanewplayerinstemcellbiology AT madhaveethumiahmootoo mitophagyanewplayerinstemcellbiology AT yanburelle mitophagyanewplayerinstemcellbiology AT mireillekhacho mitophagyanewplayerinstemcellbiology |
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